Synergy of antiviral actions of TNF and IFN-γ

Evidence for a major role of TNF-induced IFN-β

Thomas K. Hughes, T. Adam Kaspar, Dorian H. Coppenhaver

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAntiviral Research
Volume10
Issue number1-3
DOIs
StatePublished - 1988

Fingerprint

Interferon-gamma
Antiviral Agents
Tumor Necrosis Factor-alpha
Antibodies

Keywords

  • IFN-γ
  • Potentiation
  • TNF

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

Synergy of antiviral actions of TNF and IFN-γ : Evidence for a major role of TNF-induced IFN-β. / Hughes, Thomas K.; Kaspar, T. Adam; Coppenhaver, Dorian H.

In: Antiviral Research, Vol. 10, No. 1-3, 1988, p. 1-9.

Research output: Contribution to journalArticle

Hughes, Thomas K. ; Kaspar, T. Adam ; Coppenhaver, Dorian H. / Synergy of antiviral actions of TNF and IFN-γ : Evidence for a major role of TNF-induced IFN-β. In: Antiviral Research. 1988 ; Vol. 10, No. 1-3. pp. 1-9.
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