Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β

Thomas K. Hughes; T. Adam Kaspar; Dorian H. Coppenhaver

doi:10.1016/0166-3542(88)90010-1

Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β

Thomas K. Hughes, T. Adam Kaspar, Dorian H. Coppenhaver

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Antiviral research
Volume	10
Issue number	1-3
DOIs	https://doi.org/10.1016/0166-3542(88)90010-1
State	Published - Nov 1988
Externally published	Yes

Keywords

IFN-γ
Potentiation
TNF

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/0166-3542(88)90010-1

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title = "Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β",

abstract = "Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.",

keywords = "IFN-γ, Potentiation, TNF",

author = "Hughes, {Thomas K.} and Kaspar, {T. Adam} and Coppenhaver, {Dorian H.}",

year = "1988",

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T1 - Synergy of antiviral actions of TNF and IFN-γ

T2 - Evidence for a major role of TNF-induced IFN-β

AU - Hughes, Thomas K.

AU - Kaspar, T. Adam

AU - Coppenhaver, Dorian H.

PY - 1988/11

Y1 - 1988/11

N2 - Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.

AB - Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.

KW - IFN-γ

KW - Potentiation

KW - TNF

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JO - Antiviral research

JF - Antiviral research

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ER -

Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β

Abstract

Keywords

ASJC Scopus subject areas

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