Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β

Thomas K. Hughes, T. Adam Kaspar, Dorian H. Coppenhaver

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25 Scopus citations


Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-γ) directly and through induction of IFN-β in HEp-2 cells. Antibody to IFN-β inhibits a large component of the TNF and IFN-γ synergy and immunoreactive IFN-β can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-β is demonstrated.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAntiviral research
Issue number1-3
StatePublished - Nov 1988



  • IFN-γ
  • Potentiation
  • TNF

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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