Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors

Amir P. Tamiz; Miles P. Smith; Istvan Enyedy; Judith Flippen-Anderson; Mei Zhang; Kenneth M. Johnson; Alan P. Kozikowski

doi:10.1016/S0960-894X(00)00308-5

Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors

Amir P. Tamiz, Miles P. Smith, Istvan Enyedy, Judith Flippen-Anderson, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	1681-1686
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(00)00308-5
State	Published - Aug 7 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00308-5

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abstract = "The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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AU - Tamiz, Amir P.

AU - Smith, Miles P.

AU - Enyedy, Istvan

AU - Flippen-Anderson, Judith

AU - Zhang, Mei

AU - Johnson, Kenneth M.

AU - Kozikowski, Alan P.

PY - 2000/8/7

Y1 - 2000/8/7

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AB - The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors

Abstract

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