Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes

New dopamine transporter inhibitors

Amir P. Tamiz, Miles P. Smith, Istvan Enyedy, Judith Flippen-Anderson, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)1681-1686
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number15
DOIs
StatePublished - Aug 7 2000

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Tropanes
Dopamine Plasma Membrane Transport Proteins
Stereochemistry
Bioactivity
Topology
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Tamiz, A. P., Smith, M. P., Enyedy, I., Flippen-Anderson, J., Zhang, M., Johnson, K. M., & Kozikowski, A. P. (2000). Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors. Bioorganic and Medicinal Chemistry Letters, 10(15), 1681-1686. https://doi.org/10.1016/S0960-894X(00)00308-5

Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes : New dopamine transporter inhibitors. / Tamiz, Amir P.; Smith, Miles P.; Enyedy, Istvan; Flippen-Anderson, Judith; Zhang, Mei; Johnson, Kenneth M.; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 15, 07.08.2000, p. 1681-1686.

Research output: Contribution to journalArticle

Tamiz, AP, Smith, MP, Enyedy, I, Flippen-Anderson, J, Zhang, M, Johnson, KM & Kozikowski, AP 2000, 'Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 15, pp. 1681-1686. https://doi.org/10.1016/S0960-894X(00)00308-5
Tamiz, Amir P. ; Smith, Miles P. ; Enyedy, Istvan ; Flippen-Anderson, Judith ; Zhang, Mei ; Johnson, Kenneth M. ; Kozikowski, Alan P. / Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes : New dopamine transporter inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 15. pp. 1681-1686.
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