Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping, John Babich, Jon A. Zubieta, Kenneth M. Johnson, Susanne Machill, Alan P. Kozikowski

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

Original languageEnglish (US)
Pages (from-to)3211-3216
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number22
DOIs
StatePublished - Nov 15 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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