Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping, John Babich, Jon A. Zubieta, Kenneth M. Johnson, Susanne Machill, Alan P. Kozikowski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

Original languageEnglish (US)
Pages (from-to)3211-3216
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number22
StatePublished - Nov 15 1999

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Dopamine Plasma Membrane Transport Proteins
Technetium
Cocaine
Rhenium
Chelation
Rats
Brain
Imaging techniques
piperidine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Hoepping, A., Babich, J., Zubieta, J. A., Johnson, K. M., Machill, S., & Kozikowski, A. P. (1999). Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. Bioorganic and Medicinal Chemistry Letters, 9(22), 3211-3216.

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. / Hoepping, Alexander; Babich, John; Zubieta, Jon A.; Johnson, Kenneth M.; Machill, Susanne; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 22, 15.11.1999, p. 3211-3216.

Research output: Contribution to journalArticle

Hoepping, A, Babich, J, Zubieta, JA, Johnson, KM, Machill, S & Kozikowski, AP 1999, 'Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine', Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 22, pp. 3211-3216.
Hoepping, Alexander ; Babich, John ; Zubieta, Jon A. ; Johnson, Kenneth M. ; Machill, Susanne ; Kozikowski, Alan P. / Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 22. pp. 3211-3216.
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