Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping; John Babich; Jon A. Zubieta; Kenneth M. Johnson; Susanne Machill; Alan P. Kozikowski

doi:10.1016/S0960-894X(99)00562-4

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping
, John Babich
, Jon A. Zubieta
, Kenneth M. Johnson
, Susanne Machill
, Alan P. Kozikowski

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

Original language	English (US)
Pages (from-to)	3211-3216
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(99)00562-4
State	Published - Nov 15 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00562-4

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abstract = "Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.",

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AU - Hoepping, Alexander

AU - Babich, John

AU - Zubieta, Jon A.

AU - Johnson, Kenneth M.

AU - Machill, Susanne

AU - Kozikowski, Alan P.

PY - 1999/11/15

Y1 - 1999/11/15

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AB - Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

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ER -

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Abstract

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