The title compounds were synthesized in good yields by the condensation reaction of diphenyl α-aminoalkylphosphonates with 2-(chloroseleno)-benzoyl chloride. Their structures were confirmed by spectroscopic methods and microanalyses. The X-ray analyses showed that the selenium-containing fused ring has a planar structure and that, by the molecular packing of the unit cells, two adjacent molecules are symmetrically linked to each other through Se(1c) ... O=P(1) bonding interactions with an intermolecular Se(1c) ... O distance of 2.797 Å. The results of bioassay indicated that some of these compounds possess potent antitumor activities against some human carcinoma cells in vitro.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Jan 1 1999|
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