Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner, Arpaporn Deeraksa, Alyssa Smith, Brian D. Wright, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Alfredo Torres, Barbara M. Judy, Christine E. Hovis, Julia K. Hilliard, Rebekah J. Mallett, Emily Cope, D. Mark Estes, Carolyn L. Cannon, Jeff G. Leid, Wiley J. Youngs

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

Original languageEnglish (US)
Pages (from-to)1739-1745
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number13 SPEC. ISS.
DOIs
StatePublished - May 2009

Fingerprint

Methicillin
Pathogens
Bacilli
Silver
Bacteria
carbene

Keywords

  • Antibiotics
  • Burkholderia
  • Carbenes
  • N-Heterocyclic carbenes
  • Nitrogen heterocycles
  • Silver

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Panzner, M. J., Deeraksa, A., Smith, A., Wright, B. D., Hindi, K. M., Kascatan-Nebioglu, A., ... Youngs, W. J. (2009). Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. European Journal of Inorganic Chemistry, (13 SPEC. ISS.), 1739-1745. https://doi.org/10.1002/ejic.200801159

Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. / Panzner, Matthew J.; Deeraksa, Arpaporn; Smith, Alyssa; Wright, Brian D.; Hindi, Khadijah M.; Kascatan-Nebioglu, Aysegul; Torres, Alfredo; Judy, Barbara M.; Hovis, Christine E.; Hilliard, Julia K.; Mallett, Rebekah J.; Cope, Emily; Estes, D. Mark; Cannon, Carolyn L.; Leid, Jeff G.; Youngs, Wiley J.

In: European Journal of Inorganic Chemistry, No. 13 SPEC. ISS., 05.2009, p. 1739-1745.

Research output: Contribution to journalArticle

Panzner, MJ, Deeraksa, A, Smith, A, Wright, BD, Hindi, KM, Kascatan-Nebioglu, A, Torres, A, Judy, BM, Hovis, CE, Hilliard, JK, Mallett, RJ, Cope, E, Estes, DM, Cannon, CL, Leid, JG & Youngs, WJ 2009, 'Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria', European Journal of Inorganic Chemistry, no. 13 SPEC. ISS., pp. 1739-1745. https://doi.org/10.1002/ejic.200801159
Panzner MJ, Deeraksa A, Smith A, Wright BD, Hindi KM, Kascatan-Nebioglu A et al. Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. European Journal of Inorganic Chemistry. 2009 May;(13 SPEC. ISS.):1739-1745. https://doi.org/10.1002/ejic.200801159
Panzner, Matthew J. ; Deeraksa, Arpaporn ; Smith, Alyssa ; Wright, Brian D. ; Hindi, Khadijah M. ; Kascatan-Nebioglu, Aysegul ; Torres, Alfredo ; Judy, Barbara M. ; Hovis, Christine E. ; Hilliard, Julia K. ; Mallett, Rebekah J. ; Cope, Emily ; Estes, D. Mark ; Cannon, Carolyn L. ; Leid, Jeff G. ; Youngs, Wiley J. / Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. In: European Journal of Inorganic Chemistry. 2009 ; No. 13 SPEC. ISS. pp. 1739-1745.
@article{801b7850a03f4f16ada560ad2edace6b,
title = "Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria",
abstract = "A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.",
keywords = "Antibiotics, Burkholderia, Carbenes, N-Heterocyclic carbenes, Nitrogen heterocycles, Silver",
author = "Panzner, {Matthew J.} and Arpaporn Deeraksa and Alyssa Smith and Wright, {Brian D.} and Hindi, {Khadijah M.} and Aysegul Kascatan-Nebioglu and Alfredo Torres and Judy, {Barbara M.} and Hovis, {Christine E.} and Hilliard, {Julia K.} and Mallett, {Rebekah J.} and Emily Cope and Estes, {D. Mark} and Cannon, {Carolyn L.} and Leid, {Jeff G.} and Youngs, {Wiley J.}",
year = "2009",
month = "5",
doi = "10.1002/ejic.200801159",
language = "English (US)",
pages = "1739--1745",
journal = "Chemische Berichte",
issn = "0009-2940",
publisher = "Wiley-VCH Verlag",
number = "13 SPEC. ISS.",

}

TY - JOUR

T1 - Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

AU - Panzner, Matthew J.

AU - Deeraksa, Arpaporn

AU - Smith, Alyssa

AU - Wright, Brian D.

AU - Hindi, Khadijah M.

AU - Kascatan-Nebioglu, Aysegul

AU - Torres, Alfredo

AU - Judy, Barbara M.

AU - Hovis, Christine E.

AU - Hilliard, Julia K.

AU - Mallett, Rebekah J.

AU - Cope, Emily

AU - Estes, D. Mark

AU - Cannon, Carolyn L.

AU - Leid, Jeff G.

AU - Youngs, Wiley J.

PY - 2009/5

Y1 - 2009/5

N2 - A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

AB - A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

KW - Antibiotics

KW - Burkholderia

KW - Carbenes

KW - N-Heterocyclic carbenes

KW - Nitrogen heterocycles

KW - Silver

UR - http://www.scopus.com/inward/record.url?scp=66149168826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149168826&partnerID=8YFLogxK

U2 - 10.1002/ejic.200801159

DO - 10.1002/ejic.200801159

M3 - Article

AN - SCOPUS:66149168826

SP - 1739

EP - 1745

JO - Chemische Berichte

JF - Chemische Berichte

SN - 0009-2940

IS - 13 SPEC. ISS.

ER -