Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner, Arpaporn Deeraksa, Alyssa Smith, Brian D. Wright, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Alfredo G. Torres, Barbara M. Judy, Christine E. Hovis, Julia K. Hilliard, Rebekah J. Mallett, Emily Cope, D. Mark Estes, Carolyn L. Cannon, Jeff G. Leid, Wiley J. Youngs

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

Original languageEnglish (US)
Pages (from-to)1739-1745
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number13 SPEC. ISS.
DOIs
StatePublished - May 1 2009

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Keywords

  • Antibiotics
  • Burkholderia
  • Carbenes
  • N-Heterocyclic carbenes
  • Nitrogen heterocycles
  • Silver

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Panzner, M. J., Deeraksa, A., Smith, A., Wright, B. D., Hindi, K. M., Kascatan-Nebioglu, A., Torres, A. G., Judy, B. M., Hovis, C. E., Hilliard, J. K., Mallett, R. J., Cope, E., Estes, D. M., Cannon, C. L., Leid, J. G., & Youngs, W. J. (2009). Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. European Journal of Inorganic Chemistry, (13 SPEC. ISS.), 1739-1745. https://doi.org/10.1002/ejic.200801159