Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner; Arpaporn Deeraksa; Alyssa Smith; Brian D. Wright; Khadijah M. Hindi; Aysegul Kascatan-Nebioglu; Alfredo G. Torres; Barbara M. Judy; Christine E. Hovis; Julia K. Hilliard; Rebekah J. Mallett; Emily Cope; D. Mark Estes; Carolyn L. Cannon; Jeff G. Leid; Wiley J. Youngs

doi:10.1002/ejic.200801159

Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner
, Arpaporn Deeraksa
, Alyssa Smith
, Brian D. Wright
, Khadijah M. Hindi
, Aysegul Kascatan-Nebioglu
, Alfredo G. Torres
, Barbara M. Judy
, Christine E. Hovis
, Julia K. Hilliard
, Rebekah J. Mallett
, Emily Cope
, D. Mark Estes
, Carolyn L. Cannon
, Jeff G. Leid
, Wiley J. Youngs

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

Original language	English (US)
Pages (from-to)	1739-1745
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	13 SPEC. ISS.
DOIs	https://doi.org/10.1002/ejic.200801159
State	Published - May 2009

Keywords

Antibiotics
Burkholderia
Carbenes
N-Heterocyclic carbenes
Nitrogen heterocycles
Silver

ASJC Scopus subject areas

Inorganic Chemistry

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10.1002/ejic.200801159

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Panzner, M. J., Deeraksa, A., Smith, A., Wright, B. D., Hindi, K. M., Kascatan-Nebioglu, A., Torres, A. G., Judy, B. M., Hovis, C. E., Hilliard, J. K., Mallett, R. J., Cope, E., Estes, D. M., Cannon, C. L., Leid, J. G., & Youngs, W. J. (2009). Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. European Journal of Inorganic Chemistry, (13 SPEC. ISS.), 1739-1745. https://doi.org/10.1002/ejic.200801159

Panzner, MJ, Deeraksa, A, Smith, A, Wright, BD, Hindi, KM, Kascatan-Nebioglu, A, Torres, AG, Judy, BM, Hovis, CE, Hilliard, JK, Mallett, RJ, Cope, E, Estes, DM, Cannon, CL, Leid, JG & Youngs, WJ 2009, 'Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria', European Journal of Inorganic Chemistry, no. 13 SPEC. ISS., pp. 1739-1745. https://doi.org/10.1002/ejic.200801159

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abstract = "A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.",

keywords = "Antibiotics, Burkholderia, Carbenes, N-Heterocyclic carbenes, Nitrogen heterocycles, Silver",

author = "Panzner, \{Matthew J.\} and Arpaporn Deeraksa and Alyssa Smith and Wright, \{Brian D.\} and Hindi, \{Khadijah M.\} and Aysegul Kascatan-Nebioglu and Torres, \{Alfredo G.\} and Judy, \{Barbara M.\} and Hovis, \{Christine E.\} and Hilliard, \{Julia K.\} and Mallett, \{Rebekah J.\} and Emily Cope and Estes, \{D. Mark\} and Cannon, \{Carolyn L.\} and Leid, \{Jeff G.\} and Youngs, \{Wiley J.\}",

year = "2009",

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doi = "10.1002/ejic.200801159",

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AU - Panzner, Matthew J.

AU - Deeraksa, Arpaporn

AU - Smith, Alyssa

AU - Wright, Brian D.

AU - Hindi, Khadijah M.

AU - Kascatan-Nebioglu, Aysegul

AU - Torres, Alfredo G.

AU - Judy, Barbara M.

AU - Hovis, Christine E.

AU - Hilliard, Julia K.

AU - Mallett, Rebekah J.

AU - Cope, Emily

AU - Estes, D. Mark

AU - Cannon, Carolyn L.

AU - Leid, Jeff G.

AU - Youngs, Wiley J.

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AB - A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

KW - Antibiotics

KW - Burkholderia

KW - Carbenes

KW - N-Heterocyclic carbenes

KW - Nitrogen heterocycles

KW - Silver

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JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 13 SPEC. ISS.

ER -

Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Abstract

Keywords

ASJC Scopus subject areas

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