Abstract
Two series of novel α-phosphoryl(thio)ureido alkanephosphonate derivatives (5,6) have been synthesized by a convenient, multistep route involving the addition reaction of phosphoryl isothiocyanides with α-aminoalkanephosphonates and a homogeneous desulphurisation utilizing Ag+-H2O system as key steps. The carbodiimide intermediate 8 in the conversion of compounds 5 into 6 was trapped to afford regioselectively the corresponding imino-ether 9 instead of its isomer 10. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 5 and 6 have potent antiphytoviral activities against the tobacco mosaic virus (TMV). In addition, some of 5 possess selective herbicidal activities and some of 5 and 6 exhibit good fungicidal activities against wheat leaf rust and cucumber grey blight.
Original language | English (US) |
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Pages (from-to) | 247-256 |
Number of pages | 10 |
Journal | Phosphorus, Sulfur and Silicon and Related Elements |
Volume | 118 |
Issue number | 1-4 |
DOIs | |
State | Published - Jan 1 1996 |
Externally published | Yes |
Keywords
- Antiphytoviral chemicals
- Desulphurisation
- Synthesis
- α-Phosphoryl(thio)ureido alkanephosphonates
- α-aminoalkanephosphonates
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Inorganic Chemistry