Synthesis and properties of novel amino acid linked phosphoryl nitrogen mustard derivatives

Ru‐Yu ‐Y Chen, Hui‐Lin ‐L Wang, Jia Zhou

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In order to look for novel antitumor drugs and virucides with high activity and low toxicity, a series of amino acid linked phosphoryl nitrogen mustard derivatives have been synthesized. The structures of all compounds prepared were confirmed by 1H NMR, 31P NMR, IR, MS spectroscopy, and elemental analyses. In the case of dl‐α‐amino acid derivatives, the presence of multiple chiral centers in the target products leads to the generation of diastereoisomers, which can be detected by spectroscopic and analytical (TLC) methods. Preliminary bioassays indicate that some of compounds 5 have high inhibitory activities against some tumor cells and tobacco mosaic virus (TMV). In addition, some of them display certain herbicidal activities and significant fungicidal activities against wheat leaf rust.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalHeteroatom Chemistry
Volume5
Issue number5-6
DOIs
StatePublished - 1994
Externally publishedYes

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Mechlorethamine
Nuclear magnetic resonance
Derivatives
Amino Acids
Tobacco
Bioassay
Viruses
Antineoplastic Agents
Toxicity
Tumors
Infrared spectroscopy
Cells
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and properties of novel amino acid linked phosphoryl nitrogen mustard derivatives. / Chen, Ru‐Yu ‐Y; Wang, Hui‐Lin ‐L; Zhou, Jia.

In: Heteroatom Chemistry, Vol. 5, No. 5-6, 1994, p. 497-501.

Research output: Contribution to journalArticle

Chen, Ru‐Yu ‐Y ; Wang, Hui‐Lin ‐L ; Zhou, Jia. / Synthesis and properties of novel amino acid linked phosphoryl nitrogen mustard derivatives. In: Heteroatom Chemistry. 1994 ; Vol. 5, No. 5-6. pp. 497-501.
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