Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives

Ru Yu Chen, Li Juan Mao, Hui Lin Wang, Jia Zhou

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Abstract

Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalPhosphorus, Sulfur, and Silicon and the Related Elements
Volume89
Issue number1-4
DOIs
StatePublished - Apr 1 1994

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Keywords

  • Antitumor
  • antivirus
  • nitrogen mustard
  • phosphoryl diamide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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