Synthesis and screening of small molecule inhibitors of anthrax edema factor

Maria Estrella Jimenez, Kathryn Bush, Jennifer Pawlik, Laurie Sower, Johnny Peterson, Scott R. Gilbertson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The synthesis and development of a novel class of molecules that inhibit anthrax edema factor, an adenylyl cyclase, is reported. These molecules are derived from the initial discovery that histidine and imidazole adducts of the prostaglandin PGE2 reduce the net secretory response of cholera toxin-challenged mice and act directly on the action of anthrax edema factor, a calmodulin-dependent adenylyl cyclase. The simple enones examined in this letter were prepared by palladium-catalyzed Suzuki reaction.

Original languageEnglish
Pages (from-to)4215-4218
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number14
DOIs
StatePublished - Jul 15 2008

Fingerprint

Adenylyl Cyclases
Screening
Molecules
Cholera Toxin
Palladium
Calmodulin
Dinoprostone
Histidine
Prostaglandins
anthrax toxin
imidazole

Keywords

  • Adeylyl cyclase
  • Antrhax
  • Edema factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and screening of small molecule inhibitors of anthrax edema factor. / Jimenez, Maria Estrella; Bush, Kathryn; Pawlik, Jennifer; Sower, Laurie; Peterson, Johnny; Gilbertson, Scott R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 14, 15.07.2008, p. 4215-4218.

Research output: Contribution to journalArticle

Jimenez, Maria Estrella ; Bush, Kathryn ; Pawlik, Jennifer ; Sower, Laurie ; Peterson, Johnny ; Gilbertson, Scott R. / Synthesis and screening of small molecule inhibitors of anthrax edema factor. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 14. pp. 4215-4218.
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