Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

Yasuyoshi Iso, Ewa Grajkowska, Jarda T. Wroblewski, Jared Davis, Nicholas E. Goeders, Kenneth M. Johnson, Subramaniam Sanker, Bryan L. Roth, Werner Tueckmantel, Alan P. Kozikowski

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Recent genetic and pharmacological studies have suggested that the metabotropic glutamate receptor subtype 5 (mGluR5) may represent a druggable target in identifying new therapeutics for the treatment of various central nervous system disorders including drug abuse. In particular, considerable attention in the mGluR5 field has been devoted to identifying ligands that bind to the allosteric modulatory site, distinct from the site for the primary agonist glutamate. Both 2-methyl-6-(phenylethynyl)pyridine (MPEP) and its analogue 3-[(2-methyl-4-thiazolyl)ethynyl]pyridine (MTEP) have been shown to be selective and potent noncompetitive antagonists of mGluR5. Because of results presented in this study showing that MTEP prevents the reinstatement of cocaine self-administration caused by the presentation of environmental cues previously associated with cocaine availability, we have prepared a series of analogues of MTEP with the aim of gaining a better understanding of the structural features relevant to its antagonist potency and with the ultimate aim of investigating the effects of such compounds in blunting the self-administration of cocaine. These efforts have led to the identification of compounds showing higher potency as mGluR5 antagonists than either MPEP or MTEP. Two compounds 19 and 59 exhibited functional activity as mGluR5 antagonists that are 490 and 230 times, respectively, better than that of MTEP.

Original languageEnglish (US)
Pages (from-to)1080-1100
Number of pages21
JournalJournal of Medicinal Chemistry
Volume49
Issue number3
DOIs
StatePublished - Feb 9 2006

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Metabotropic Glutamate 5 Receptor
Metabotropic Glutamate Receptors
Structure-Activity Relationship
Cocaine
Self Administration
Allosteric Site
Excitatory Amino Acid Agonists
Central Nervous System Diseases
Neurology
Substance-Related Disorders
Cues
3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine
pyridine
Pharmacology
Ligands
Availability
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. / Iso, Yasuyoshi; Grajkowska, Ewa; Wroblewski, Jarda T.; Davis, Jared; Goeders, Nicholas E.; Johnson, Kenneth M.; Sanker, Subramaniam; Roth, Bryan L.; Tueckmantel, Werner; Kozikowski, Alan P.

In: Journal of Medicinal Chemistry, Vol. 49, No. 3, 09.02.2006, p. 1080-1100.

Research output: Contribution to journalArticle

Iso, Yasuyoshi ; Grajkowska, Ewa ; Wroblewski, Jarda T. ; Davis, Jared ; Goeders, Nicholas E. ; Johnson, Kenneth M. ; Sanker, Subramaniam ; Roth, Bryan L. ; Tueckmantel, Werner ; Kozikowski, Alan P. / Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 3. pp. 1080-1100.
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