Synthesis and utilization of 13C(8)-enriched purines

Christopher J. LaFrancois, June Fujimoto, Lawrence C. Sowers

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A new and more efficient method is presented for the synthesis of 13C(8)-enriched adenine. In addition, we present for the first time the synthesis of 13C(8)-enriched 2-aminopurine and purine. All three analogues have been converted to the corresponding ribonucleosides. The adenine analogue has been further converted to the 2'-deoxy-nucleoside and incorporated into a synthetic oligonucleotide. Data is presented demonstrating the utility of 13C-enrichment in heteronuclear isotope- edited NMR spectra.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalNucleosides and Nucleotides
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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