Abstract
4′-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4′-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells.
Original language | English (US) |
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Pages (from-to) | 1198-1201 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2010 |
Externally published | Yes |
Keywords
- Anticancer activity
- Gemcitabine
- Heck coupling
- Melanoma
- Resveratrol
- Stilbene
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry