Synthesis of 4′-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines

Yong Wong, Gregory Osmond, Kenneth I. Brewer, Douglas S. Tyler, Merritt B. Andrus

Research output: Contribution to journalArticle

16 Scopus citations


4′-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4′-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells.

Original languageEnglish (US)
Pages (from-to)1198-1201
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - Feb 1 2010



  • Anticancer activity
  • Gemcitabine
  • Heck coupling
  • Melanoma
  • Resveratrol
  • Stilbene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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