Synthesis of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates as microtubule targeting and apoptosis inducing agents

Keyphrases

• Microtubules 100%
• Benzo 100%
• MDA-MB-231 100%
• Anti-apoptotic Agent 100%
• Thiazole 100%
• Imidazo 100%
• Chalcone 100%
• Induced Apoptosis 50%
• Cell Cycle Arrest 50%
• Antiproliferative Activity 50%
• Lung 50%
• Colon Cancer 50%
• Morphological Changes 50%
• HT-29 50%
• Biological Studies 50%
• Cancer Cell Lines 50%
• Computational Study 50%
• IC50 Value 50%
• Breast 50%
• Mechanistic Aspects 50%
• Flow Cytometric Analysis 50%
• Binding Mode 50%
• Human Breast Cancer 50%
• A549 50%
• M Phase 50%
• DU145 50%
• Microtubule Assembly 50%
• Molecular Docking Studies 50%
• In Silico 50%
• MDA-MB-231 Cancer Cells 50%
• Annexin 50%
• Tubulin Protein 50%
• Diacetate 50%
• Tubulin Polymerization 50%
• Polymerization Assays 50%
• Reactive Oxygen Species Assay 50%
• Cytotoxic Potency 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Tubulin 100%
• Chalcone 100%
• Thiazole 100%
• Reactive Oxygen Metabolite 50%
• Breast Cancer 50%
• IC50 50%
• Colon Carcinoma 50%
• Acetoacetic Acid 50%
• Lipocortin 50%