Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

A. G. Balya, A. N. Chernega, Sergii Buth, A. N. Vasilenko, V. S. Brovarets, B. S. Drach

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

Original languageEnglish (US)
Pages (from-to)1427-1435
Number of pages9
JournalRussian Journal of General Chemistry
Volume78
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

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Thiohydantoins
Thiazoles
Thiourea
Condensation
Derivatives
Hydrochloric Acid
Hydrolysis
Ethanol
Heating
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas. / Balya, A. G.; Chernega, A. N.; Buth, Sergii; Vasilenko, A. N.; Brovarets, V. S.; Drach, B. S.

In: Russian Journal of General Chemistry, Vol. 78, No. 7, 07.2008, p. 1427-1435.

Research output: Contribution to journalArticle

Balya, A. G. ; Chernega, A. N. ; Buth, Sergii ; Vasilenko, A. N. ; Brovarets, V. S. ; Drach, B. S. / Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas. In: Russian Journal of General Chemistry. 2008 ; Vol. 78, No. 7. pp. 1427-1435.
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