Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

A. G. Balya; A. N. Chernega; S. A. But; A. N. Vasilenko; V. S. Brovarets; B. S. Drach

doi:10.1134/S1070363208070268

Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

A. G. Balya, A. N. Chernega, S. A. But, A. N. Vasilenko, V. S. Brovarets, B. S. Drach

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

Original language	English (US)
Pages (from-to)	1427-1435
Number of pages	9
Journal	Russian Journal of General Chemistry
Volume	78
Issue number	7
DOIs	https://doi.org/10.1134/S1070363208070268
State	Published - Jul 2008
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1134/S1070363208070268

Cite this

@article{efc67d71b64743cd8ef9d2914cd7b574,

title = "Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas",

abstract = "N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.",

author = "Balya, {A. G.} and Chernega, {A. N.} and But, {S. A.} and Vasilenko, {A. N.} and Brovarets, {V. S.} and Drach, {B. S.}",

note = "Funding Information: This study was performed under financial support by the Ukrainian Science and Technology Center [project no. 3017(R)].",

year = "2008",

month = jul,

doi = "10.1134/S1070363208070268",

language = "English (US)",

volume = "78",

pages = "1427--1435",

journal = "Russian Journal of General Chemistry",

issn = "1070-3632",

publisher = "Pleiades Publishing",

number = "7",

}

TY - JOUR

T1 - Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

AU - Balya, A. G.

AU - Chernega, A. N.

AU - But, S. A.

AU - Vasilenko, A. N.

AU - Brovarets, V. S.

AU - Drach, B. S.

N1 - Funding Information: This study was performed under financial support by the Ukrainian Science and Technology Center [project no. 3017(R)].

PY - 2008/7

Y1 - 2008/7

N2 - N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

AB - N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

UR - http://www.scopus.com/inward/record.url?scp=55049136160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55049136160&partnerID=8YFLogxK

U2 - 10.1134/S1070363208070268

DO - 10.1134/S1070363208070268

M3 - Article

AN - SCOPUS:55049136160

SN - 1070-3632

VL - 78

SP - 1427

EP - 1435

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

IS - 7

ER -

Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this