Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

A. G. Balya, A. N. Chernega, Sergii Buth, A. N. Vasilenko, V. S. Brovarets, B. S. Drach

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4 Scopus citations


N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N′-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

Original languageEnglish (US)
Pages (from-to)1427-1435
Number of pages9
JournalRussian Journal of General Chemistry
Issue number7
StatePublished - Jul 2008
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)

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