Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites

Lawrence C. Sowers, G. Peter Beardsley

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

Original languageEnglish (US)
Pages (from-to)1664-1665
Number of pages2
JournalJournal of Organic Chemistry
Volume58
Issue number7
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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