Synthesis of oligonucleotides containing 5-(hydroxymethyl)-2′-deoxyuridine at defined sites

Lawrence Sowers, G. Peter Beardsley

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

Original languageEnglish (US)
Pages (from-to)1664-1665
Number of pages2
JournalJournal of Organic Chemistry
Volume58
Issue number7
StatePublished - 1993
Externally publishedYes

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Oligonucleotides
Oxidation
DNA
5-hydroxymethyl-2'-deoxyuridine
phosphoramidite

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of oligonucleotides containing 5-(hydroxymethyl)-2′-deoxyuridine at defined sites. / Sowers, Lawrence; Beardsley, G. Peter.

In: Journal of Organic Chemistry, Vol. 58, No. 7, 1993, p. 1664-1665.

Research output: Contribution to journalArticle

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