Synthesis of oligonucleotides containing bulky adducts at guanine N2 via the phosphoramidite of O2-triflate-O6-NPE 2'-deoxyxanthosine

Monica D. Cooper, Richard P. Hodge, Pamela J. Tamura, Amanda S. Wilkinson, Constance M. Harris, Thomas M. Harris

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Oligodeoxynucleotides bearing bulky adducts at guanine N2 have been prepared by a postoligomerization strategy in which oligonucleotides containing a highly reactive O2-trifluoromethanesulfonyl-O6-(p- nitrophenethyl) 2'-deoxyxanthosine residue were reacted with (±)-10β-amino- 7,8,9,10-tetrahydro-benzo [a]pyrene-7β,8α,9α-triol and related compounds. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3555-3558
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number19
DOIs
StatePublished - May 6 2000

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Keywords

  • Nucleic acids
  • Nucleosides
  • Polycyclic aromatic compounds
  • Purines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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