Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization

Zonghui Ma; Ge Gao; Haiying Sun

doi:10.1016/j.tetlet.2021.152847

Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization

Zonghui Ma, Ge Gao, Haiying Sun

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pyridopyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones are valuable scaffolds which can be used in drug development. In this letter a simple and efficient method for the synthesis of pyrido[4,3–d]pyrimidine-2,4-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization of easily synthesized 5,6,7,8-tetrahydropyrido[4,3–d]pyrimidine-2,4(1H,3H)-dione derivatives was reported.

Original language	English (US)
Article number	152847
Journal	Tetrahedron Letters
Volume	67
DOIs	https://doi.org/10.1016/j.tetlet.2021.152847
State	Published - Mar 16 2021
Externally published	Yes

Keywords

Cerium ammonium nitrate
Oxidative aromatization
Pyridopyrimidinediones

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2021.152847

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@article{f05a23bf6705456c94824f3f1d27289c,

title = "Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization",

abstract = "Pyridopyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones are valuable scaffolds which can be used in drug development. In this letter a simple and efficient method for the synthesis of pyrido[4,3–d]pyrimidine-2,4-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization of easily synthesized 5,6,7,8-tetrahydropyrido[4,3–d]pyrimidine-2,4(1H,3H)-dione derivatives was reported.",

keywords = "Cerium ammonium nitrate, Oxidative aromatization, Pyridopyrimidinediones",

author = "Zonghui Ma and Ge Gao and Haiying Sun",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = mar,

day = "16",

doi = "10.1016/j.tetlet.2021.152847",

language = "English (US)",

volume = "67",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization

AU - Ma, Zonghui

AU - Gao, Ge

AU - Sun, Haiying

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Pyridopyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones are valuable scaffolds which can be used in drug development. In this letter a simple and efficient method for the synthesis of pyrido[4,3–d]pyrimidine-2,4-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization of easily synthesized 5,6,7,8-tetrahydropyrido[4,3–d]pyrimidine-2,4(1H,3H)-dione derivatives was reported.

AB - Pyridopyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones are valuable scaffolds which can be used in drug development. In this letter a simple and efficient method for the synthesis of pyrido[4,3–d]pyrimidine-2,4-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization of easily synthesized 5,6,7,8-tetrahydropyrido[4,3–d]pyrimidine-2,4(1H,3H)-dione derivatives was reported.

KW - Cerium ammonium nitrate

KW - Oxidative aromatization

KW - Pyridopyrimidinediones

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DO - 10.1016/j.tetlet.2021.152847

M3 - Article

AN - SCOPUS:85100811441

SN - 0040-4039

VL - 67

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 152847

ER -

Synthesis of pyrido[4,3–d]pyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization

Abstract

Keywords

ASJC Scopus subject areas

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