Synthesis of vitamin D in skin after burns

Gordon L. Klein, Tai C. Chen, Michael F. Holick, Craig B. Langman, Heather Price, Mario M. Celis, David Herndon

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

Original languageEnglish (US)
Pages (from-to)291-292
Number of pages2
JournalLancet
Volume363
Issue number9405
DOIs
StatePublished - Jan 24 2004

Fingerprint

Burns
Vitamin D
Skin
Vitamin D Deficiency
Bone Remodeling
Cholecalciferol
Wounds and Injuries
Solar System
Ultraviolet Rays
Homeostasis
Calcium
Biopsy
Serum
previtamin D(3)
25-hydroxyvitamin D
Provitamins
7-dehydrocholesterol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Klein, G. L., Chen, T. C., Holick, M. F., Langman, C. B., Price, H., Celis, M. M., & Herndon, D. (2004). Synthesis of vitamin D in skin after burns. Lancet, 363(9405), 291-292. https://doi.org/10.1016/S0140-6736(03)15388-3

Synthesis of vitamin D in skin after burns. / Klein, Gordon L.; Chen, Tai C.; Holick, Michael F.; Langman, Craig B.; Price, Heather; Celis, Mario M.; Herndon, David.

In: Lancet, Vol. 363, No. 9405, 24.01.2004, p. 291-292.

Research output: Contribution to journalArticle

Klein, GL, Chen, TC, Holick, MF, Langman, CB, Price, H, Celis, MM & Herndon, D 2004, 'Synthesis of vitamin D in skin after burns', Lancet, vol. 363, no. 9405, pp. 291-292. https://doi.org/10.1016/S0140-6736(03)15388-3
Klein GL, Chen TC, Holick MF, Langman CB, Price H, Celis MM et al. Synthesis of vitamin D in skin after burns. Lancet. 2004 Jan 24;363(9405):291-292. https://doi.org/10.1016/S0140-6736(03)15388-3
Klein, Gordon L. ; Chen, Tai C. ; Holick, Michael F. ; Langman, Craig B. ; Price, Heather ; Celis, Mario M. ; Herndon, David. / Synthesis of vitamin D in skin after burns. In: Lancet. 2004 ; Vol. 363, No. 9405. pp. 291-292.
@article{a244ae7baa5d47fca56973fc3aa3eac1,
title = "Synthesis of vitamin D in skin after burns",
abstract = "Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.",
author = "Klein, {Gordon L.} and Chen, {Tai C.} and Holick, {Michael F.} and Langman, {Craig B.} and Heather Price and Celis, {Mario M.} and David Herndon",
year = "2004",
month = "1",
day = "24",
doi = "10.1016/S0140-6736(03)15388-3",
language = "English (US)",
volume = "363",
pages = "291--292",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9405",

}

TY - JOUR

T1 - Synthesis of vitamin D in skin after burns

AU - Klein, Gordon L.

AU - Chen, Tai C.

AU - Holick, Michael F.

AU - Langman, Craig B.

AU - Price, Heather

AU - Celis, Mario M.

AU - Herndon, David

PY - 2004/1/24

Y1 - 2004/1/24

N2 - Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

AB - Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

UR - http://www.scopus.com/inward/record.url?scp=0942300659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0942300659&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(03)15388-3

DO - 10.1016/S0140-6736(03)15388-3

M3 - Article

VL - 363

SP - 291

EP - 292

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9405

ER -