Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent

Chen Yue-Jian, Tao Juan, Xiong Fei, Zhu Jia-Bi, Gu Ning, Zhang Yi-Hua, Ding Ye, Ge Liang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Aim: Investigated the self-assembly and characterization of novel antifouling polyethylene glycol (PEG)-coated iron oxide nanoparticles as nanoprobes for magnetic resonance imaging (MRI) contrast agent. Method: Monodisperse oleic acid-coated superparamagnetic iron oxide cores are synthesized by thermal decomposition of iron oleate. The self-assembly behavior between iron oxide cores and PEG-lipid conjugates in water and their characteristics are confirmed by transmission electron microscope, X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. Result: Dynamic light scattering shows superparamagnetic iron oxide nanoparticles coated with PEG are stable in water for pH of 310 and ionic strengths up to 0.3 M NaCl, and are protein resistant in physiological conditions. Additionally, in vitro MRI study demonstrates the efficient magnetic resonance imaging contrast characteristics of the iron oxide nanoparticles. Conclusion: The result indicates that the novel antifouling PEG-coated superparamagnetic iron oxide nanoparticles could potentially be used in a wide range of applications such as biotechnology, MRI, and magnetic fluid hyperthermia.

Original languageEnglish (US)
Pages (from-to)1235-1244
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume36
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Magnetic resonance
Nanoparticles
Self assembly
Contrast Media
Magnetic Resonance Imaging
Imaging techniques
Oleic Acid
Nanoprobes
Magnetic fluids
Water
Magnetometers
Dynamic light scattering
Fourier Transform Infrared Spectroscopy
Biotechnology
Ionic strength
X-Ray Diffraction
Osmolar Concentration
Thermogravimetric analysis
ferric oxide
Pyrolysis

Keywords

  • CMC
  • Magnetic nanoparticles
  • Monodisperse
  • MRI
  • Self-assembly
  • Superparamagnetic iron oxide nanoparticles
  • Thermal decomposition

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

Cite this

Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent. / Yue-Jian, Chen; Juan, Tao; Fei, Xiong; Jia-Bi, Zhu; Ning, Gu; Yi-Hua, Zhang; Ye, Ding; Liang, Ge.

In: Drug Development and Industrial Pharmacy, Vol. 36, No. 10, 10.2010, p. 1235-1244.

Research output: Contribution to journalArticle

Yue-Jian, Chen ; Juan, Tao ; Fei, Xiong ; Jia-Bi, Zhu ; Ning, Gu ; Yi-Hua, Zhang ; Ye, Ding ; Liang, Ge. / Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent. In: Drug Development and Industrial Pharmacy. 2010 ; Vol. 36, No. 10. pp. 1235-1244.
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