Systemic alterations in ornithine decarboxylase activity caused by colon cancer in mice

R. Saydjari, R. D. Beauchamp, C. M. Townsend, J. C. Thompson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a ratelimiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity in the gastrointestinal tract, kidney and liver of mice. Forty-four Balb/c mice were randomly divided into 2 groups and the test group was pair-fed (to control). Group 1 was the tumor-free control. Group 2 was inoculated subcutaneously with 5 × 105 MC-26 cells. The ODC activity in the kidney and liver of tumor-bearing mice was significantly lower compared to tumor-free controls at sacrifice. ODC activity in the colon increased almost 4-fold. These results suggest that the presence of MC-26 tumor causes systemic effects that alter ODC activity. The tumor may elaborate a substance that suppresses ODC activity in some normal tissues while stimulating ODC activity in the tissue from which the tumor was derived.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalCancer Letters
Volume58
Issue number1-2
DOIs
StatePublished - Jun 14 1991

Keywords

  • cancer
  • ornithine decarboxylase
  • polyamines
  • tumor burden

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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