Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration

A. Roca-Cusachs, D. J. DiPette, J. Carson, G. A. Graham, O. B. Holland

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate the cardiovascular effects of 1,25-dihydroxyvitamin D3 (1,25-D). Design: Recent studies suggest that Ca-regulating hormones may contribute to the genesis of hypertension. We determined systemic and regional hemodynamics 24h after administration of 1,25-D or vehicle to normal conscious Sprague Dawley rats. In addition, to dissociate the vascular effects of 1 25-D from changes in serum ionized Ca2+, 1,25-D and vehicle were administered to rats maintained for 3 days on a low-Ca diet. To evaluate the effect of the slight rise in serum ionized Ca2+ with 1,25-D administration, we infused CaCl or vehicle over 1 h into normal rats to raise the serum Ca2+ to near that of rats treated with 1,25-D. Methods: The radioactive microsphere technique was used. Results: Systemic hemodynamics (blood pressure, heart rate, cardiac output, total peripheral resistance and stroke volume) did not differ between the two groups receiving a normal-Ca diet. In these rats 1,25-D significantly decreased renal blood flow (RBF), increased renal vascular resistance (RVR) and slightly increased serum ionized Ca2+. Similarly, in rats receiving a low-Ca diet, 1,25-D administration decreased renal blood flow, increased renal vascular resistance and caused only a minimal increase in serum ionized Ca2+. A low-Ca diet also increased heart rate, cardiac blood flow and renal blood flow. Although CaCl infusion raised serum ionized Ca2+, blood pressure, renal blood flow and renal vascular resistance did not change significantly. Conclusion: 1,25-D may constrict the renal vasculature directly or indirectly by enhancing the vascular sensitivity to circulating vasoconstrictors.

Original languageEnglish (US)
Pages (from-to)939-947
Number of pages9
JournalJournal of Hypertension
Volume10
Issue number9
StatePublished - 1992

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Calcitriol
Renal Circulation
Hemodynamics
Vascular Resistance
Serum
Diet
Kidney
Blood Vessels
Heart Rate
Blood Pressure
Vasoconstrictor Agents
Microspheres
Cardiac Output
Stroke Volume
Sprague Dawley Rats
Hormones
Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

Cite this

Roca-Cusachs, A., DiPette, D. J., Carson, J., Graham, G. A., & Holland, O. B. (1992). Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration. Journal of Hypertension, 10(9), 939-947.

Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration. / Roca-Cusachs, A.; DiPette, D. J.; Carson, J.; Graham, G. A.; Holland, O. B.

In: Journal of Hypertension, Vol. 10, No. 9, 1992, p. 939-947.

Research output: Contribution to journalArticle

Roca-Cusachs, A, DiPette, DJ, Carson, J, Graham, GA & Holland, OB 1992, 'Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration', Journal of Hypertension, vol. 10, no. 9, pp. 939-947.
Roca-Cusachs A, DiPette DJ, Carson J, Graham GA, Holland OB. Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration. Journal of Hypertension. 1992;10(9):939-947.
Roca-Cusachs, A. ; DiPette, D. J. ; Carson, J. ; Graham, G. A. ; Holland, O. B. / Systemic and regional hemodynamic effects of 1,25-dihydroxyvitamin D3 administration. In: Journal of Hypertension. 1992 ; Vol. 10, No. 9. pp. 939-947.
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