Systemic and regional hemodynamic effects of calcitonin gene-related peptide

D. J. DiPette, K. Schwarzenberger, N. Kerr, O. B. Holland

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Calcitonin gene-related peptide, a 37-amino-acid neuropeptide, has been shown to be widely distributed in periadventitial nerves throughout the cardiovascular system, particularly in association with coronary arteries. In vivo and in vitro studies have demonstrated that calcitonin gene-related peptide possesses potent vasodilator properties. Circulating calcitonin gene-related peptide is derived primarily from periadventitial nerves, though its systemic and regional hemodynamic effects are unknown. In this study, systemic and regional hemodynamics were determined by the radioactive microsphere technique prior to and following the intravenous administration of 65-pmol and 2.2-nmol doses of calcitonin gene-related peptide and vehicle to three groups of conscious, unrestrained rats. Vehicle administration did not change any systemic or regional organ hemodynamic parameter determined. In contrast, 65 pmol and 2.2 nmol of calcitonin gene-related peptide significantly decreased mean blood pressure and total peripheral resistance and increased heart rate in a dose-dependent manner, while only slightly increasing cardiac output. Both 65-pmol and 2.2-nmol doses of calcitonin gene-related peptide significantly increased blood flow (percentage of cardiac output) to the heart. There was no difference in blood flow to the heart between the two doses. In addition, the 2.2-nmol dose of calcitonin gene-related peptide significantly increased blood flow to the stomach, liver, and skin and decreased it to the brain, kidneys, and spleen. In conclusion, calcitonin gene-related peptide infusion decreases blood pressure in a dose-dependent manner primarily by peripheral vasodilation. In addition, calcitonin gene-related peptide selectively changes regional organ blood flow, particularly to cause coronary vasodilation. Therefore, calcitonin gene-related peptide may have an important role in blood pressure and regional organ blood flow regulation.

Original languageEnglish (US)
JournalHypertension
Volume9
Issue number6 II SUPPL.
StatePublished - 1987

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Calcitonin Gene-Related Peptide
Hemodynamics
Regional Blood Flow
Blood Pressure
Vasodilation
Cardiac Output
Cardiovascular System
Neuropeptides
Vasodilator Agents
Microspheres
Intravenous Administration
Vascular Resistance
Coronary Vessels
Stomach
Spleen
Heart Rate
Kidney
Amino Acids
Skin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

DiPette, D. J., Schwarzenberger, K., Kerr, N., & Holland, O. B. (1987). Systemic and regional hemodynamic effects of calcitonin gene-related peptide. Hypertension, 9(6 II SUPPL.).

Systemic and regional hemodynamic effects of calcitonin gene-related peptide. / DiPette, D. J.; Schwarzenberger, K.; Kerr, N.; Holland, O. B.

In: Hypertension, Vol. 9, No. 6 II SUPPL., 1987.

Research output: Contribution to journalArticle

DiPette, DJ, Schwarzenberger, K, Kerr, N & Holland, OB 1987, 'Systemic and regional hemodynamic effects of calcitonin gene-related peptide', Hypertension, vol. 9, no. 6 II SUPPL..
DiPette DJ, Schwarzenberger K, Kerr N, Holland OB. Systemic and regional hemodynamic effects of calcitonin gene-related peptide. Hypertension. 1987;9(6 II SUPPL.).
DiPette, D. J. ; Schwarzenberger, K. ; Kerr, N. ; Holland, O. B. / Systemic and regional hemodynamic effects of calcitonin gene-related peptide. In: Hypertension. 1987 ; Vol. 9, No. 6 II SUPPL.
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