Systemic infection of avian influenza A virus H5N1 subtype in humans

Zengfeng Zhang, Jinxia Zhang, Kai Huang, Kang Sheng Li, Kwok Yung Yuen, Yi Guan, Honglin Chen, Wai Fu Ng

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease.

Original languageEnglish (US)
Pages (from-to)735-739
Number of pages5
JournalHuman Pathology
Volume40
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Influenza in Birds
Influenza A virus
Respiratory System
Viral Antigens
Infection
H5N1 Subtype Influenza A Virus
Hemophagocytic Lymphohistiocytosis
Lung
Nucleoproteins
Zoonoses
Neuroglia
Bone Marrow Cells
Epithelial Cells
Lymphocytes
Pathology
Neurons
Brain

Keywords

  • Avian influenza A virus
  • H5N1 subtype
  • Human infection
  • Immunohistochemistry
  • Tissue tropism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Zhang, Z., Zhang, J., Huang, K., Li, K. S., Yuen, K. Y., Guan, Y., ... Ng, W. F. (2009). Systemic infection of avian influenza A virus H5N1 subtype in humans. Human Pathology, 40(5), 735-739. https://doi.org/10.1016/j.humpath.2008.08.015

Systemic infection of avian influenza A virus H5N1 subtype in humans. / Zhang, Zengfeng; Zhang, Jinxia; Huang, Kai; Li, Kang Sheng; Yuen, Kwok Yung; Guan, Yi; Chen, Honglin; Ng, Wai Fu.

In: Human Pathology, Vol. 40, No. 5, 01.05.2009, p. 735-739.

Research output: Contribution to journalArticle

Zhang, Z, Zhang, J, Huang, K, Li, KS, Yuen, KY, Guan, Y, Chen, H & Ng, WF 2009, 'Systemic infection of avian influenza A virus H5N1 subtype in humans', Human Pathology, vol. 40, no. 5, pp. 735-739. https://doi.org/10.1016/j.humpath.2008.08.015
Zhang, Zengfeng ; Zhang, Jinxia ; Huang, Kai ; Li, Kang Sheng ; Yuen, Kwok Yung ; Guan, Yi ; Chen, Honglin ; Ng, Wai Fu. / Systemic infection of avian influenza A virus H5N1 subtype in humans. In: Human Pathology. 2009 ; Vol. 40, No. 5. pp. 735-739.
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