Systemic lupus erythematosus is associated with increased adverse postoperative renal outcomes and mortality: A historical cohort study using administrative health data

Rovnat Babazade, Huseyin Oguz Yilmaz, Steve M. Leung, Nicole M. Zimmerman, Alparslan Turan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease that mainly harms kidneys, heart, lungs, and nervous system. Effects of surgical stimulus and anesthesia combined with SLE-related pathologies may increase morbidity and mortality. Therefore, we aimed to evaluate the association between SLE (versus none) and postoperative renal, cardiac, and in-hospital mortality complications among patients undergoing major surgeries. Methods: We obtained censuses of 2009 to 2011 inpatient hospital discharges across 7 states and conducted a retrospective cohort study by using International Classification of Diseases and Injuries, Version 9, diagnosis codes, procedure codes, and present-on-admission indicators. We included patients who had major surgery and matched each SLE discharge up to 4 control discharges for potential confounders. We assessed the association between matched SLE patients and controls on in-hospital renal complications, cardiovascular complications, and in-hospital mortality using separate logistic regression models. Results: Among 8 million qualifying discharges, our sample contained 28,269 SLE patients matched with 13,269 controls. SLE was associated with a significantly higher risk of postoperative renal complications, with an estimated odds ratio (99% CI) of 1.33 (1.21, 1.46); P < .001. In addition, SLE was significantly associated with a higher risk of in-hospital mortality, with an estimated odds ratio (99% CI) of 1.27 (1.11, 1.47); P < .001. However, we found no significant association between SLE and cardiac complications, with an estimated odds ratio (99% CI) of 0.98 (0.83, 1.16), P = .79. Conclusions: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period.

Original languageEnglish (US)
Pages (from-to)1118-1126
Number of pages9
JournalAnesthesia and Analgesia
Volume124
Issue number4
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Cohort Studies
Kidney
Mortality
Health
Hospital Mortality
Odds Ratio
Logistic Models
Perioperative Period
Connective Tissue Diseases
Wounds and Injuries
International Classification of Diseases
Censuses
Nervous System
Inpatients
Anesthesia
Retrospective Studies
Pathology
Morbidity
Lung

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Systemic lupus erythematosus is associated with increased adverse postoperative renal outcomes and mortality : A historical cohort study using administrative health data. / Babazade, Rovnat; Yilmaz, Huseyin Oguz; Leung, Steve M.; Zimmerman, Nicole M.; Turan, Alparslan.

In: Anesthesia and Analgesia, Vol. 124, No. 4, 01.01.2017, p. 1118-1126.

Research output: Contribution to journalArticle

@article{352bffa12b9645adaec93988da2d7e06,
title = "Systemic lupus erythematosus is associated with increased adverse postoperative renal outcomes and mortality: A historical cohort study using administrative health data",
abstract = "Background: Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease that mainly harms kidneys, heart, lungs, and nervous system. Effects of surgical stimulus and anesthesia combined with SLE-related pathologies may increase morbidity and mortality. Therefore, we aimed to evaluate the association between SLE (versus none) and postoperative renal, cardiac, and in-hospital mortality complications among patients undergoing major surgeries. Methods: We obtained censuses of 2009 to 2011 inpatient hospital discharges across 7 states and conducted a retrospective cohort study by using International Classification of Diseases and Injuries, Version 9, diagnosis codes, procedure codes, and present-on-admission indicators. We included patients who had major surgery and matched each SLE discharge up to 4 control discharges for potential confounders. We assessed the association between matched SLE patients and controls on in-hospital renal complications, cardiovascular complications, and in-hospital mortality using separate logistic regression models. Results: Among 8 million qualifying discharges, our sample contained 28,269 SLE patients matched with 13,269 controls. SLE was associated with a significantly higher risk of postoperative renal complications, with an estimated odds ratio (99{\%} CI) of 1.33 (1.21, 1.46); P < .001. In addition, SLE was significantly associated with a higher risk of in-hospital mortality, with an estimated odds ratio (99{\%} CI) of 1.27 (1.11, 1.47); P < .001. However, we found no significant association between SLE and cardiac complications, with an estimated odds ratio (99{\%} CI) of 0.98 (0.83, 1.16), P = .79. Conclusions: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period.",
author = "Rovnat Babazade and Yilmaz, {Huseyin Oguz} and Leung, {Steve M.} and Zimmerman, {Nicole M.} and Alparslan Turan",
year = "2017",
month = "1",
day = "1",
doi = "10.1213/ANE.0000000000001911",
language = "English (US)",
volume = "124",
pages = "1118--1126",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Systemic lupus erythematosus is associated with increased adverse postoperative renal outcomes and mortality

T2 - A historical cohort study using administrative health data

AU - Babazade, Rovnat

AU - Yilmaz, Huseyin Oguz

AU - Leung, Steve M.

AU - Zimmerman, Nicole M.

AU - Turan, Alparslan

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease that mainly harms kidneys, heart, lungs, and nervous system. Effects of surgical stimulus and anesthesia combined with SLE-related pathologies may increase morbidity and mortality. Therefore, we aimed to evaluate the association between SLE (versus none) and postoperative renal, cardiac, and in-hospital mortality complications among patients undergoing major surgeries. Methods: We obtained censuses of 2009 to 2011 inpatient hospital discharges across 7 states and conducted a retrospective cohort study by using International Classification of Diseases and Injuries, Version 9, diagnosis codes, procedure codes, and present-on-admission indicators. We included patients who had major surgery and matched each SLE discharge up to 4 control discharges for potential confounders. We assessed the association between matched SLE patients and controls on in-hospital renal complications, cardiovascular complications, and in-hospital mortality using separate logistic regression models. Results: Among 8 million qualifying discharges, our sample contained 28,269 SLE patients matched with 13,269 controls. SLE was associated with a significantly higher risk of postoperative renal complications, with an estimated odds ratio (99% CI) of 1.33 (1.21, 1.46); P < .001. In addition, SLE was significantly associated with a higher risk of in-hospital mortality, with an estimated odds ratio (99% CI) of 1.27 (1.11, 1.47); P < .001. However, we found no significant association between SLE and cardiac complications, with an estimated odds ratio (99% CI) of 0.98 (0.83, 1.16), P = .79. Conclusions: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period.

AB - Background: Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease that mainly harms kidneys, heart, lungs, and nervous system. Effects of surgical stimulus and anesthesia combined with SLE-related pathologies may increase morbidity and mortality. Therefore, we aimed to evaluate the association between SLE (versus none) and postoperative renal, cardiac, and in-hospital mortality complications among patients undergoing major surgeries. Methods: We obtained censuses of 2009 to 2011 inpatient hospital discharges across 7 states and conducted a retrospective cohort study by using International Classification of Diseases and Injuries, Version 9, diagnosis codes, procedure codes, and present-on-admission indicators. We included patients who had major surgery and matched each SLE discharge up to 4 control discharges for potential confounders. We assessed the association between matched SLE patients and controls on in-hospital renal complications, cardiovascular complications, and in-hospital mortality using separate logistic regression models. Results: Among 8 million qualifying discharges, our sample contained 28,269 SLE patients matched with 13,269 controls. SLE was associated with a significantly higher risk of postoperative renal complications, with an estimated odds ratio (99% CI) of 1.33 (1.21, 1.46); P < .001. In addition, SLE was significantly associated with a higher risk of in-hospital mortality, with an estimated odds ratio (99% CI) of 1.27 (1.11, 1.47); P < .001. However, we found no significant association between SLE and cardiac complications, with an estimated odds ratio (99% CI) of 0.98 (0.83, 1.16), P = .79. Conclusions: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period.

UR - http://www.scopus.com/inward/record.url?scp=85017305400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017305400&partnerID=8YFLogxK

U2 - 10.1213/ANE.0000000000001911

DO - 10.1213/ANE.0000000000001911

M3 - Article

C2 - 28319545

AN - SCOPUS:85017305400

VL - 124

SP - 1118

EP - 1126

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 4

ER -