Systemic lupus erythematosus occurring in a patient with epidermolysis bullosa acquisita

A. D. Dotson, Sharon Raimer, T. V. Pursley, J. Tschen

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Abstract

A dystrophic bullous eruption that met all the criteria for epidermolysis bullosa acquisita (EBA) developed in a 19-year-old woman five years before the onset of clinical and serologic evidence of systemic lupus erythematosus (SLE). Electron microscopic studies of skin lesions both before and after the development of SLE were consistent with the previously reported electron microscopic findings in patients with EBA. Direct immunofluorescence microscopic studies done on bullae before and after the diagnosis of SLE showed linear depositions of immunoglobulin and complement; indirect immunofluorescence microscopic study findings consistently showed no abnormalities. These findings have been noted in other cases of EBA and may implicate autoimmune, immunologic factors in the pathogenesis of the disease process. To our knowledge, the finding of SLE in association with EBA has not been previously reported.

Original languageEnglish (US)
Pages (from-to)422-426
Number of pages5
JournalArchives of Dermatology
Volume117
Issue number7
DOIs
StatePublished - 1981

Fingerprint

Epidermolysis Bullosa Acquisita
Systemic Lupus Erythematosus
Electrons
Direct Fluorescent Antibody Technique
Immunologic Factors
Blister
Indirect Fluorescent Antibody Technique
Immunoglobulins
Skin

ASJC Scopus subject areas

  • Dermatology

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Systemic lupus erythematosus occurring in a patient with epidermolysis bullosa acquisita. / Dotson, A. D.; Raimer, Sharon; Pursley, T. V.; Tschen, J.

In: Archives of Dermatology, Vol. 117, No. 7, 1981, p. 422-426.

Research output: Contribution to journalArticle

Dotson, A. D. ; Raimer, Sharon ; Pursley, T. V. ; Tschen, J. / Systemic lupus erythematosus occurring in a patient with epidermolysis bullosa acquisita. In: Archives of Dermatology. 1981 ; Vol. 117, No. 7. pp. 422-426.
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