Syzygium cumini seed extract protects the liver against lipid peroxidation with concurrent amelioration of hepatic enzymes and lipid profile of alcoholic rats

Shahdat Hossain, Imrul Hasan Chowdhury, Mafroz Ahmed Basunia, Taslima Nahar, Asiqur Rahaman, Bazlur Karim Choudhury, Shahabuddin Kabir Choudhuri, Ishtiaq Mahmud, Borhan Uddin

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The in vitro oxidative stress induced by ethanol/Fenton's reaction in rat liver homogenates decreased significantly in the presence of Syzygium cumini seed extract, suggesting the protective effect of the seed extract against the oxidative stress in liver. To corroborate the in vitro effects by an in vivo experiment, 24 rats were divided into four groups: control, S. cumini seed-extract-administered (SE), 15% ethanol-fed (Alc) and Alc+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 7 weeks significantly decreased the levels of liver LPO in the Alc+SE rats, suggesting that S. cumini seed not only obstructed the in vitro free radical production and subsequent oxidative stress, but also inhibited their in vivo formation. The oral administration of extract also reduced the enzyme activities of serum gammaglutamyl transferase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase and the levels of serum creatinine and blood urea nitrogen, serum/liver triglycerides and total cholesterol of the alcoholic rats. The levels of fecal cholesterol were increased by the extract. Fatty degenerations in liver and kidney were absent with S. cumini seed extract treatment. The results suggest that S. cumini seed may be a potential therapy for alcoholics and related dysfunctions by restraining oxidative stress.

Original languageEnglish (US)
Article number1
JournalJournal of Complementary and Integrative Medicine
Volume8
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Syzygium cumini seed extract
  • alcoholics
  • hepatotoxicity and hypercholesterolemia
  • lipid peroxidation

ASJC Scopus subject areas

  • Complementary and alternative medicine

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