TY - JOUR
T1 - T cells mediate cross-protective immunity between spotted fever group rickettsiae and typhus group rickettsiae
AU - Valbuena, Gustavo
AU - Jordan, Jeffrey M.
AU - Walker, David H.
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Diseases (grant RO1 AI21242 to D.H.W.); College of American Pathologists Foundation Scholars Research Fellowship (to G.V.); James W. McLaughlin Predoctoral Fellowship (to G.V.).
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Rickettsioses are severe infections caused by obligately intracellular bacteria that preferentially infect the endothelium lining the vasculature. The causative agents, rickettsiae, have been divided according to biological, genetic, and antigenic parameters into 2 main groups: spotted fever and typhus. They have not been thought to stimulate cross-reactive protective immune responses; however, in this study, we show that, in relevant animal models that mimic human rickettsial infections, there is reciprocal immunological cross-protection between spotted fever group and typhus group rickettsiae. Furthermore, we present evidence that T cells are responsible for this cross-immunity and that cross-stimulation of T cells also occurs in humans.
AB - Rickettsioses are severe infections caused by obligately intracellular bacteria that preferentially infect the endothelium lining the vasculature. The causative agents, rickettsiae, have been divided according to biological, genetic, and antigenic parameters into 2 main groups: spotted fever and typhus. They have not been thought to stimulate cross-reactive protective immune responses; however, in this study, we show that, in relevant animal models that mimic human rickettsial infections, there is reciprocal immunological cross-protection between spotted fever group and typhus group rickettsiae. Furthermore, we present evidence that T cells are responsible for this cross-immunity and that cross-stimulation of T cells also occurs in humans.
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U2 - 10.1086/423819
DO - 10.1086/423819
M3 - Article
C2 - 15346331
AN - SCOPUS:4644293408
SN - 0022-1899
VL - 190
SP - 1221
EP - 1227
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -