T helper type 1 cells in asthma: Friend or foe?

Robin Stephens, Stephanie C. Eisenbarth, David D. Chaplin

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalCurrent opinion in allergy and clinical immunology
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'T helper type 1 cells in asthma: Friend or foe?'. Together they form a unique fingerprint.

  • Cite this