T helper type 1 cells in asthma: Friend or foe?

Robin Stephens, Stephanie C. Eisenbarth, David D. Chaplin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume2
Issue number1
StatePublished - 2002
Externally publishedYes

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Th1 Cells
Th2 Cells
Asthma
Helper-Inducer T-Lymphocytes
Cell Differentiation
Research Personnel
Inflammation
Research

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T helper type 1 cells in asthma : Friend or foe? / Stephens, Robin; Eisenbarth, Stephanie C.; Chaplin, David D.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 2, No. 1, 2002, p. 31-37.

Research output: Contribution to journalArticle

Stephens, Robin ; Eisenbarth, Stephanie C. ; Chaplin, David D. / T helper type 1 cells in asthma : Friend or foe?. In: Current Opinion in Allergy and Clinical Immunology. 2002 ; Vol. 2, No. 1. pp. 31-37.
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