T helper type 1 cells in asthma: Friend or foe?

Robin Stephens, Stephanie C. Eisenbarth, David D. Chaplin

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalCurrent opinion in allergy and clinical immunology
Issue number1
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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