Tachykinin receptors as drug targets for motility disorders

Willemijntje A. Hoogerwerf, Sushil K. Sarna

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalDigestive Diseases
Volume24
Issue number1-2
DOIs
StatePublished - May 1 2006

Keywords

  • Gastrointestinal motility
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Prokinetics agents
  • Tachykinins

ASJC Scopus subject areas

  • Gastroenterology

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