Tacrolimus dosing requirements and concentrations in adult living donor liver transplant recipients

David J. Taber, Robert E. Dupuis, Amy L. Fann, Kenneth A. Andreoni, David A. Gerber, Jeffrey Fair, Mark W. Johnson, Roshan Shrestha

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Living donor liver transplantation in adult recipients is becoming increasingly common. The liver metabolizes most drugs, including immunosuppressive agents. Right-lobe grafts used in adult living donor liver transplantation consist of only 50% to 60% of the total liver. The purpose of this study is to determine whether there is a difference between tacrolimus doses and concentrations in patients who received a partial liver transplant from a living donor (LRD) versus those who received a whole-liver transplant from a cadaveric donor (CAD). Thirteen LRD recipients and 13 CAD recipients who underwent transplantation between April 1998 and July 2000 were included in this analysis. A CAD control group matched for age, sex, and race was used for comparison. Tacrolimus doses and concentrations were analyzed weekly for the first 4 weeks, then monthly for 6 months posttransplantation. There was no difference in acute rejection rates, renal and liver function test results, or number of potentially interacting medications administered between groups. LRD recipients required significantly lower doses of tacrolimus compared with CAD recipients at 2 weeks (0.058 v 0.110 mg/kg/d; P 15 ng/mL; 22.1% v 9.2%; P <.01). In conclusion, LRD recipients have significantly decreased tacrolimus dosing requirements compared with CAD recipients during the first 3 months posttransplantation despite having similar tacrolimus concentrations.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalLiver Transplantation
Volume8
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Taber, D. J., Dupuis, R. E., Fann, A. L., Andreoni, K. A., Gerber, D. A., Fair, J., Johnson, M. W., & Shrestha, R. (2002). Tacrolimus dosing requirements and concentrations in adult living donor liver transplant recipients. Liver Transplantation, 8(3), 219-223. https://doi.org/10.1053/jlts.2002.30885