Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Jie Yan, Mingxi Yao, Benjamin T. Goult, Michael Sheetz

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing proteins and converted into signals that direct cells to adapt to the external environment. A key function of cell adhesion to the extracellular matrix (ECM) is to transduce mechanical forces between cells and their extracellular environment. Talin, a cytoplasmic adapter essential for integrin-mediated adhesion to the ECM, links the actin cytoskeleton to integrin at the plasma membrane. Here, we review recent progress in the understanding of talin-dependent mechanosensing revealed by stretching single talin molecules. Rapid progress in single-molecule force manipulation technologies has made it possible to directly study the impact of mechanical force on talin’s conformations and its interactions with other signaling proteins. We also provide our views on how findings from such studies may bring new insights into understanding the principles of mechanobiology on a broader scale, and how such fundamental knowledge may be harnessed for mechanopharmacology.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalCellular and Molecular Bioengineering
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Cell adhesion
  • Magnetic tweezers
  • Mechanosensing
  • Talin
  • Vinculin

ASJC Scopus subject areas

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)

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