TY - JOUR
T1 - Targeting body composition in an older population
T2 - do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial
AU - on behalf of the PREDIMED-Plus investigators
AU - Galmes-Panades, Aina M.
AU - Konieczna, Jadwiga
AU - Varela-Mato, Veronica
AU - Abete, Itziar
AU - Babio, Nancy
AU - Fiol, Miquel
AU - Antonio de Paz, José
AU - Casas, Rosa
AU - Olbeyra, Romina
AU - Ruiz-Canela, Miguel
AU - Palau-Galindo, Antoni
AU - Castañer, Olga
AU - Martín-García, Arturo
AU - Estruch, Ramón
AU - Vidal, Josep
AU - Buil-Cosiales, Pilar
AU - Wärnberg, Julia
AU - Salas-Salvadó, Jordi
AU - Martínez, J. Alfredo
AU - Romaguera, Dora
AU - Martin, V.
AU - Pedret-Llaberia, R.
AU - Gonzalez, R.
AU - Sagarra-Álamo, R.
AU - París-Palleja, F.
AU - Balsells, J.
AU - Roca, J. M.
AU - Basora-Gallisa, T.
AU - Vizcaino, J.
AU - Llobet-Alpizarte, P.
AU - Anguera-Perpiñá, C.
AU - Llauradó-Vernet, M.
AU - Caballero, C.
AU - Garcia-Barco, M.
AU - Morán-Martínez, M. D.
AU - García-Rosselló, J.
AU - del Pozo, A.
AU - Poblet-Calaf, C.
AU - Arcelin-Zabal, P.
AU - Floresví, X.
AU - Ciutat-Benet, M.
AU - Cabré-Vila, J. J.
AU - Dolz-Andrés, F.
AU - Soler, M.
AU - Garcia-Vidal, M.
AU - Vilalta, J.
AU - Boj Casajuana, J.
AU - Ricard, M.
AU - Saiz, F.
AU - López, D.
N1 - Funding Information:
The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926); the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to Jordi Salas-Salvadó; the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the Astra Zeneca Young Investigators Award in Category of Obesity and Diabetes 2017 to Dora Romaguera; the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands) to Jadwiga Konieczna. JR17/00022 contract to Olga Castaner from ISCIII. CIBERobn (Centros de Investigación Biomedica en Red: Obesidad y Nutrición), CIBEResp (Centros de Investigación Biomedica en Red: Epidemiología y Salud Publica) and CIBERdem (Centros de Investigación Biomedica en Red: Diabetes y Enfermedades). J. Salas-Salvadó author gratefully acknowledges the financial support by ICREA under the ICREA Academia programme. None of the funding sources took part in the design, collection, analysis or interpretation of the data and in writing the manuscript or in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults. Methods: Longitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55–75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants’ body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models. Results: Increasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (β − 0.07% and − 0.08%) and visceral adipose tissue (VAT) (− 13.9 g, and − 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001). Conclusions: At 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA. Trial registration: International Standard Randomized Controlled Trial (ISRCTN), 89898870.
AB - Background: The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults. Methods: Longitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55–75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants’ body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models. Results: Increasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (β − 0.07% and − 0.08%) and visceral adipose tissue (VAT) (− 13.9 g, and − 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001). Conclusions: At 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA. Trial registration: International Standard Randomized Controlled Trial (ISRCTN), 89898870.
KW - Body composition
KW - Isotemporal substitution
KW - Physical activity
KW - Sedentary behaviour
KW - Visceral adipose tissue
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UR - http://www.scopus.com/inward/citedby.url?scp=85098791895&partnerID=8YFLogxK
U2 - 10.1186/s12916-020-01847-9
DO - 10.1186/s12916-020-01847-9
M3 - Article
C2 - 33402165
AN - SCOPUS:85098791895
SN - 1741-7015
VL - 19
JO - BMC Medicine
JF - BMC Medicine
IS - 1
M1 - 3
ER -