Targeting dengue virus NS4B protein for drug discovery

Xuping Xie, Jing Zou, Qing Yin Wang, Pei-Yong Shi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Original languageEnglish (US)
Article number3603
Pages (from-to)39-45
Number of pages7
JournalAntiviral Research
Volume118
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Dengue Virus
Drug Discovery
Flavivirus
Proteins
Antiviral Agents
Research

Keywords

  • Antivirals
  • Dengue
  • Flavivirus
  • Nonstructural protein 4B
  • NS4B

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

Targeting dengue virus NS4B protein for drug discovery. / Xie, Xuping; Zou, Jing; Wang, Qing Yin; Shi, Pei-Yong.

In: Antiviral Research, Vol. 118, 3603, 2015, p. 39-45.

Research output: Contribution to journalArticle

Xie, Xuping ; Zou, Jing ; Wang, Qing Yin ; Shi, Pei-Yong. / Targeting dengue virus NS4B protein for drug discovery. In: Antiviral Research. 2015 ; Vol. 118. pp. 39-45.
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