Targeting dengue virus NS4B protein for drug discovery

Xuping Xie, Jing Zou, Qing Yin Wang, Pei Yong Shi

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Original languageEnglish (US)
Article number3603
Pages (from-to)39-45
Number of pages7
JournalAntiviral research
StatePublished - Jun 2015
Externally publishedYes


  • Antivirals
  • Dengue
  • Flavivirus
  • NS4B
  • Nonstructural protein 4B

ASJC Scopus subject areas

  • Pharmacology
  • Virology


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