Targeting dengue virus NS4B protein for drug discovery

Xuping Xie; Jing Zou; Qing Yin Wang; Pei Yong Shi

doi:10.1016/j.antiviral.2015.03.007

Targeting dengue virus NS4B protein for drug discovery

Xuping Xie
, Jing Zou
, Qing Yin Wang
, Pei Yong Shi

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Original language	English (US)
Article number	3603
Pages (from-to)	39-45
Number of pages	7
Journal	Antiviral research
Volume	118
DOIs	https://doi.org/10.1016/j.antiviral.2015.03.007
State	Published - Jun 2015

Keywords

Antivirals
Dengue
Flavivirus
NS4B
Nonstructural protein 4B

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/j.antiviral.2015.03.007

Cite this

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title = "Targeting dengue virus NS4B protein for drug discovery",

abstract = "Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.",

keywords = "Antivirals, Dengue, Flavivirus, NS4B, Nonstructural protein 4B",

author = "Xuping Xie and Jing Zou and Wang, \{Qing Yin\} and Shi, \{Pei Yong\}",

year = "2015",

month = jun,

doi = "10.1016/j.antiviral.2015.03.007",

language = "English (US)",

volume = "118",

pages = "39--45",

journal = "Antiviral research",

issn = "0166-3542",

publisher = "Elsevier B.V.",

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AU - Xie, Xuping

AU - Zou, Jing

AU - Wang, Qing Yin

AU - Shi, Pei Yong

PY - 2015/6

Y1 - 2015/6

N2 - Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

AB - Abstract The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

KW - Antivirals

KW - Dengue

KW - Flavivirus

KW - NS4B

KW - Nonstructural protein 4B

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UR - https://www.scopus.com/pages/publications/84925855875#tab=citedBy

U2 - 10.1016/j.antiviral.2015.03.007

DO - 10.1016/j.antiviral.2015.03.007

M3 - Review article

C2 - 25796970

AN - SCOPUS:84925855875

SN - 0166-3542

VL - 118

SP - 39

EP - 45

JO - Antiviral research

JF - Antiviral research

M1 - 3603

ER -

Targeting dengue virus NS4B protein for drug discovery

Abstract

Keywords

ASJC Scopus subject areas

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