Targeting of motor proteins

Richard B. Vallee, Michael Sheetz

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules. How these proteins are targeted to the appropriate organellar sites within the cell, however, has remained a mystery. Recent work has begun to define the targeting mechanism for two well-studied motor proteins, kinesin and cytoplasmic dynein.

Original languageEnglish (US)
Pages (from-to)1539-1544
Number of pages6
JournalScience
Volume271
Issue number5255
DOIs
StatePublished - Mar 15 1996
Externally publishedYes

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Protein Transport
Microtubules
Cytoplasmic Dyneins
Kinesin
Chromosome Segregation
Proteins
Organelles

ASJC Scopus subject areas

  • General

Cite this

Targeting of motor proteins. / Vallee, Richard B.; Sheetz, Michael.

In: Science, Vol. 271, No. 5255, 15.03.1996, p. 1539-1544.

Research output: Contribution to journalArticle

Vallee, Richard B. ; Sheetz, Michael. / Targeting of motor proteins. In: Science. 1996 ; Vol. 271, No. 5255. pp. 1539-1544.
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