Tataguine virus infection in mice and hamsters

A. H. Fagbami, T. P. Monath, F. A. Murphy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Suckling hamsters, weanling and suckling mice, inoculated intracerebrally with Tataguine virus consistently developed fatal infections with average survival time of 3-8 days. Deaths were observed in a few suckling hamsters infected by the hamsters showed that the brain was the only organ in which viral replication occurred. Histopathological lesions found in the brain of such mice and hamsters infected by intracerebral or intraperitoneal inoculations included neuronal degeneration and necrosis, interstitial and perivascular oedema of the cerebral cortex and the spinal cord, leucocytic infiltration and perivascular cuffing. Thin section electron microscopy of infected mouse brains revealed the presence of bunyavirus-like particles within the cytoplasmic vacuoles of neurons.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalMicrobios
Volume27
Issue number108
StatePublished - Dec 1 1980

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Fagbami, A. H., Monath, T. P., & Murphy, F. A. (1980). Tataguine virus infection in mice and hamsters. Microbios, 27(108), 89-96.