Taurine deficiency in the kitten subcellular distribution of taurine and [35S]taurine in brain

D. K. Rassin, J. A. Sturman, K. C. Hayes, G. E. Gaull

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Taurine concentration decreases rapidly in the tissues and physiological fluids of kittens fed a diet of partially purified casein which lacks taurine. We have studied the subcellular distribution in cerebrum of taurine and [35S]taurine administered intravenously to these animals. The taurine concentration of all the fractions isolated from the cerebrum of taurine-deficient kittens was approximately sevenfold less than that observed in the fractions of cerebrum isolated from control kittens. The [35S]taurine was approximately twofold greater in all the brain fractions isolated from the taurine-deficient kittens compared with those isolated from the control kittens. The percent distributions of taurine and [35S]taurine in the fractions isolated from the cerebrum of control and deficient kittens were identical. Thus, in the face of a severe diet-induced deficiency of taurine in kitten brain, there appears to be no conservation of taurine by any particular subcellular pool of taurine. These studies provide no evidence for differences in compartmentation of taurine in cerebrum of taurine-deficient kittens compared with control kittens.

Original languageEnglish (US)
Pages (from-to)401-410
Number of pages10
JournalNeurochemical Research
Volume3
Issue number4
DOIs
StatePublished - Aug 1978
Externally publishedYes

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Taurine
Brain
Cerebrum
Nutrition
Diet
Caseins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Taurine deficiency in the kitten subcellular distribution of taurine and [35S]taurine in brain. / Rassin, D. K.; Sturman, J. A.; Hayes, K. C.; Gaull, G. E.

In: Neurochemical Research, Vol. 3, No. 4, 08.1978, p. 401-410.

Research output: Contribution to journalArticle

Rassin, D. K. ; Sturman, J. A. ; Hayes, K. C. ; Gaull, G. E. / Taurine deficiency in the kitten subcellular distribution of taurine and [35S]taurine in brain. In: Neurochemical Research. 1978 ; Vol. 3, No. 4. pp. 401-410.
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