Abstract
The transfer of [35S]taurine, injected intraperitoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S]taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-39 |
| Number of pages | 9 |
| Journal | Journal of Neurochemistry |
| Volume | 28 |
| Issue number | 1 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
Taurine in developing rat brain : maternal fetal transfer of [35S] taurine and its fate in the neonate. / Sturman, J. A.; Rassin, D. K.; Gaull, G. E.
In: Journal of Neurochemistry, Vol. 28, No. 1, 1977, p. 31-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Taurine in developing rat brain
T2 - maternal fetal transfer of [35S] taurine and its fate in the neonate
AU - Sturman, J. A.
AU - Rassin, D. K.
AU - Gaull, G. E.
PY - 1977
Y1 - 1977
N2 - The transfer of [35S]taurine, injected intraperitoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S]taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover.
AB - The transfer of [35S]taurine, injected intraperitoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S]taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017328715&partnerID=8YFLogxK
M3 - Article
C2 - 833601
AN - SCOPUS:0017328715
VL - 28
SP - 31
EP - 39
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 1
ER -