Taurine in developing rat brain

maternal fetal transfer of [35S] taurine and its fate in the neonate

J. A. Sturman, D. K. Rassin, G. E. Gaull

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The transfer of [35S]taurine, injected intraperitoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S]taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalJournal of Neurochemistry
Volume28
Issue number1
StatePublished - 1977
Externally publishedYes

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Taurine
Rats
Brain
Mothers
Parturition
Liver
Radioactivity
Dams
Fetus
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Taurine in developing rat brain : maternal fetal transfer of [35S] taurine and its fate in the neonate. / Sturman, J. A.; Rassin, D. K.; Gaull, G. E.

In: Journal of Neurochemistry, Vol. 28, No. 1, 1977, p. 31-39.

Research output: Contribution to journalArticle

Sturman, J. A. ; Rassin, D. K. ; Gaull, G. E. / Taurine in developing rat brain : maternal fetal transfer of [35S] taurine and its fate in the neonate. In: Journal of Neurochemistry. 1977 ; Vol. 28, No. 1. pp. 31-39.
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