TAURINE IN DEVELOPING RAT BRAIN: MATERNAL‐FETAL TRANSFER OF [35S]TAURINE AND ITS FATE IN THE NEONATE

J. A. Sturman, D. K. Rassin, G. E. Gaull

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The transfer of [35] taunne, injected intrapentoneally into pregnant rats (near term), to fetal tissues has been measured. Taurine can enter fetal brain as easily as it can fetal liver. In contrast, it cannot enter mature brain as easily as it can enter mature liver. After birth, [35S] taurine, which had been injected into the dam before birth of the pups, continues to accumulate in the brain of the pups for some days. During the neonatal period, the concentration of taurine is decreasing, but the total pool of taurine in the brain is increasing rapidly. In order to help supply this increasing pool, the taurine present in the brain at birth appears to be conserved and an increasing amount of taurine is synthesized in situ. The net result during the neonatal period of development is that brain taurine specific radioactivity decreases and brain taurine has a very slow rate of turnover.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalJournal of neurochemistry
Volume28
Issue number1
DOIs
StatePublished - Jan 1977

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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