Taurine in developing rat brain: Transfer of [35S]taurine to pups via the milk

J. A. Sturman, D. K. Rassin, G. E. Gaull

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The concentration of taurine in rat milk is very high for the first few days after birth and then falls rapidly. [35S]Taurine injected intraperitoneally into lactating dams after birth was transferred via the milk to the pups, and accumulated in the brains of the pups to a greater extent than in the livers of the pups. Maximal accumulation of [35S]taurine so transferred to the brain of the pups was reached by 5 days after birth, and remained constant for at least 10 days beyond this point. The specific radioactivity in the brain of the pups also reached a maximal value at 5 days after birth and thereafter declined because of the expanding pool of unlabeled taurine in brain. At 5 days after birth, each pup has received approximately 4 μmol taurine from the mother via the milk, and a minimum of 7% of the total taurine in brain at this time originated from the milk. Even in the rat, a species which can synthesize taurine very easily from cysteine and methionine precursors, a significant amount of preformed taurine is transferred to the developing animal via the milk. We suggest that the human infant, who cannot synthesize adequate taurine from cysteine and methionin precursors (9, 10, 40), may be dependent on its diet as a taurine source. Human milk contains a high concentration of taurine, whereas synthetic formulas contain virtually none. Taurine may be an essential nutrient for the rapidly growing human infant (and may be for the adult human also) and perhaps should be included as a supplement in synthetic formulas.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalPediatric Research
Volume11
Issue number1 I I
StatePublished - 1977
Externally publishedYes

Fingerprint

Taurine
Milk
Brain
Parturition
Cysteine
Human Milk
Methionine
Radioactivity
Mothers
Diet

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Sturman, J. A., Rassin, D. K., & Gaull, G. E. (1977). Taurine in developing rat brain: Transfer of [35S]taurine to pups via the milk. Pediatric Research, 11(1 I I), 28-33.

Taurine in developing rat brain : Transfer of [35S]taurine to pups via the milk. / Sturman, J. A.; Rassin, D. K.; Gaull, G. E.

In: Pediatric Research, Vol. 11, No. 1 I I, 1977, p. 28-33.

Research output: Contribution to journalArticle

Sturman, JA, Rassin, DK & Gaull, GE 1977, 'Taurine in developing rat brain: Transfer of [35S]taurine to pups via the milk', Pediatric Research, vol. 11, no. 1 I I, pp. 28-33.
Sturman, J. A. ; Rassin, D. K. ; Gaull, G. E. / Taurine in developing rat brain : Transfer of [35S]taurine to pups via the milk. In: Pediatric Research. 1977 ; Vol. 11, No. 1 I I. pp. 28-33.
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