Telemetric left ventricular monitoring using wireless telemetry in the rabbit model

Mallory K. Tate, William Lawrence, Randy L. Gourley, Diana L. Zavala, Lori E. Weaver, Scott T. Moen, Johnny Peterson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Heart failure is a critical condition that affects many people and often results from left ventricular dysfunction. Numerous studies investigating this condition have been performed using various model systems. To do so, investigators must be able to accurately measure myocardial performance in order to determine the degree of left ventricular function. In this model development study, we employ a wireless telemetry system purchased from Data Sciences International to continuously assess left ventricular function in the rabbit model. Findings. We surgically implanted pressure-sensitive catheters fitted to wireless radio-transmitters into the left ventricle of Dutch-belted rabbits. Following recovery of the animals, we continuously recorded indices of cardiac contractility and ventricular relaxation at baseline for a given time period. The telemetry system allowed us to continuously record baseline left ventricular parameters for the entire recording period. During this time, the animals were unrestrained and fully conscious. The values we recorded are similar to those obtained using other reported methods. Conclusions: The wireless telemetry system can continuously measure left ventricular pressure, cardiac contractility, and cardiac relaxation in the rabbit model. These results, which were obtained just as baseline levels, substantiate the need for further validation in this model system of left ventricular assessment.

Original languageEnglish (US)
Article number320
JournalBMC Research Notes
Volume4
DOIs
StatePublished - 2011

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Telemetry
Telemetering
Rabbits
Left Ventricular Function
Monitoring
Left Ventricular Dysfunction
Ventricular Pressure
Radio
Animals
Information Systems
Heart Ventricles
Radio transmitters
Catheters
Heart Failure
Research Personnel
Pressure
Recovery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Telemetric left ventricular monitoring using wireless telemetry in the rabbit model. / Tate, Mallory K.; Lawrence, William; Gourley, Randy L.; Zavala, Diana L.; Weaver, Lori E.; Moen, Scott T.; Peterson, Johnny.

In: BMC Research Notes, Vol. 4, 320, 2011.

Research output: Contribution to journalArticle

Tate, Mallory K. ; Lawrence, William ; Gourley, Randy L. ; Zavala, Diana L. ; Weaver, Lori E. ; Moen, Scott T. ; Peterson, Johnny. / Telemetric left ventricular monitoring using wireless telemetry in the rabbit model. In: BMC Research Notes. 2011 ; Vol. 4.
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