Telomere length and neighborhood circumstances: Evaluating biological response to unfavorable exposures

Shannon M. Lynch, Nandita Mitra, Krithika Ravichandran, Jonathan Mitchell, Elaine Spangler, Wenting Zhou, Electra D. Paskett, Sarah Gehlert, Cecilia DeGraffinreid, Raymond Stowe, Tamara Dubowitz, Harold Riethman, Charles C. Branas, Mary Peek, Timothy R. Rebbeck

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Multilevel frameworks suggest neighborhood circumstances influence biology; however, this relationship is not well studied. Telomere length (TL) shortening has been associated with individual-level and neighborhood-level exposures and disease and may provide insights into underlying biologic mechanisms linking neighborhood with biology. To support neighborhood-biology investigations, we sought to determine the independent effect of neighborhood exposures on TL using standard multilevel linear regression models and quantile regression, a nonlinear, social science method applicable for testing the biologic hypothesis that extremes of the TL distribution are related to poor outcomes. Methods: In a multicenter, cross-sectional study, blood TL was measured in 1,488 individuals from 127 census tracts in three U.S. regions using terminal restriction fragment assays. Multilevel linear and quantile regression models were adjusted for individual-level race, education, perceived stress, and depression. Neighborhood exposures included population density, urban/residential crowding, residential stability/mobility, and socioeconomic status. Results: TL was not associated with any neighborhood variable using linear models, but quantile regression revealed inverse associations between population density and urban crowding at the lower tails of the TL distribution [5th (population density P 0.03; urban crowding P 0.002), 50th (both P < 0.001), 75th percentiles (both P < 0.001)]. TL was related to residential stability at the upper tail (95th percentile P 0.006). Conclusions: Findings support the use of nonlinear statistical methods in TL research and suggest that neighborhood exposures can result in biological effects. Impact: TL may serve as an underlying example of a biologic mechanism that can link neighborhood with biology, thus supporting multilevel investigations in future studies.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2017

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Telomere
Crowding
Linear Models
Population Density
Telomere Shortening
Social Sciences
Population Dynamics
Censuses
Social Class
Cross-Sectional Studies
Depression
Education

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Telomere length and neighborhood circumstances : Evaluating biological response to unfavorable exposures. / Lynch, Shannon M.; Mitra, Nandita; Ravichandran, Krithika; Mitchell, Jonathan; Spangler, Elaine; Zhou, Wenting; Paskett, Electra D.; Gehlert, Sarah; DeGraffinreid, Cecilia; Stowe, Raymond; Dubowitz, Tamara; Riethman, Harold; Branas, Charles C.; Peek, Mary; Rebbeck, Timothy R.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 26, No. 4, 01.04.2017, p. 553-560.

Research output: Contribution to journalArticle

Lynch, SM, Mitra, N, Ravichandran, K, Mitchell, J, Spangler, E, Zhou, W, Paskett, ED, Gehlert, S, DeGraffinreid, C, Stowe, R, Dubowitz, T, Riethman, H, Branas, CC, Peek, M & Rebbeck, TR 2017, 'Telomere length and neighborhood circumstances: Evaluating biological response to unfavorable exposures', Cancer Epidemiology Biomarkers and Prevention, vol. 26, no. 4, pp. 553-560. https://doi.org/10.1158/1055-9965.EPI-16-0554
Lynch, Shannon M. ; Mitra, Nandita ; Ravichandran, Krithika ; Mitchell, Jonathan ; Spangler, Elaine ; Zhou, Wenting ; Paskett, Electra D. ; Gehlert, Sarah ; DeGraffinreid, Cecilia ; Stowe, Raymond ; Dubowitz, Tamara ; Riethman, Harold ; Branas, Charles C. ; Peek, Mary ; Rebbeck, Timothy R. / Telomere length and neighborhood circumstances : Evaluating biological response to unfavorable exposures. In: Cancer Epidemiology Biomarkers and Prevention. 2017 ; Vol. 26, No. 4. pp. 553-560.
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T1 - Telomere length and neighborhood circumstances

T2 - Evaluating biological response to unfavorable exposures

AU - Lynch, Shannon M.

AU - Mitra, Nandita

AU - Ravichandran, Krithika

AU - Mitchell, Jonathan

AU - Spangler, Elaine

AU - Zhou, Wenting

AU - Paskett, Electra D.

AU - Gehlert, Sarah

AU - DeGraffinreid, Cecilia

AU - Stowe, Raymond

AU - Dubowitz, Tamara

AU - Riethman, Harold

AU - Branas, Charles C.

AU - Peek, Mary

AU - Rebbeck, Timothy R.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Multilevel frameworks suggest neighborhood circumstances influence biology; however, this relationship is not well studied. Telomere length (TL) shortening has been associated with individual-level and neighborhood-level exposures and disease and may provide insights into underlying biologic mechanisms linking neighborhood with biology. To support neighborhood-biology investigations, we sought to determine the independent effect of neighborhood exposures on TL using standard multilevel linear regression models and quantile regression, a nonlinear, social science method applicable for testing the biologic hypothesis that extremes of the TL distribution are related to poor outcomes. Methods: In a multicenter, cross-sectional study, blood TL was measured in 1,488 individuals from 127 census tracts in three U.S. regions using terminal restriction fragment assays. Multilevel linear and quantile regression models were adjusted for individual-level race, education, perceived stress, and depression. Neighborhood exposures included population density, urban/residential crowding, residential stability/mobility, and socioeconomic status. Results: TL was not associated with any neighborhood variable using linear models, but quantile regression revealed inverse associations between population density and urban crowding at the lower tails of the TL distribution [5th (population density P 0.03; urban crowding P 0.002), 50th (both P < 0.001), 75th percentiles (both P < 0.001)]. TL was related to residential stability at the upper tail (95th percentile P 0.006). Conclusions: Findings support the use of nonlinear statistical methods in TL research and suggest that neighborhood exposures can result in biological effects. Impact: TL may serve as an underlying example of a biologic mechanism that can link neighborhood with biology, thus supporting multilevel investigations in future studies.

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