Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams

Kunju Sathishkumar, Meena Balakrishnan, Vijayakumar Chinnathambi, Haijun Gao, Chandra Yallampalli

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    OBJECTIVE: Examine temporal alterations in vascular angiotensin II receptors (AT 1R and AT 2R) and determine vascular response to angiotensin II in growth-restricted offspring. STUDY DESIGN: Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared. RESULTS: Prenatal protein restriction reprogrammed AT 1aR messenger RNA expression in male rats' mesenteric arteries to cause 1.7- and 2.3-fold increases at 3 and 6 months of age associated with arterial pressure increases of 10 and 33 mm Hg, respectively; however, in female rats, increased AT 1aR expression (2-fold) and arterial pressure (15 mm Hg) occurred only at 6 months. Prenatal protein restriction did not affect AT 2R expression. Losartan abolished hypertension, suggesting that AT 1aR plays a primary role in arterial pressure elevation. Vasoconstriction to angiotensin II was exaggerated in all protein-restricted offspring, with greater potency and efficacy in male rats. CONCLUSION: Prenatal protein restriction increased vascular AT 1R expression and vasoconstriction to angiotensin II, possibly contributing to programmed hypertension.

    Original languageEnglish (US)
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume206
    Issue number6
    DOIs
    StatePublished - Jun 2012

    Fingerprint

    Angiotensin Receptors
    Blood Vessels
    Angiotensin II
    Arterial Pressure
    Vasoconstriction
    Proteins
    Hypertension
    Mesenteric Arteries
    Losartan
    Diet
    Messenger RNA
    Growth

    Keywords

    • angiotensin
    • fetal programming
    • hypertension
    • intrauterine growth restriction
    • rats
    • vascular

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams. / Sathishkumar, Kunju; Balakrishnan, Meena; Chinnathambi, Vijayakumar; Gao, Haijun; Yallampalli, Chandra.

    In: American Journal of Obstetrics and Gynecology, Vol. 206, No. 6, 06.2012.

    Research output: Contribution to journalArticle

    Sathishkumar, Kunju ; Balakrishnan, Meena ; Chinnathambi, Vijayakumar ; Gao, Haijun ; Yallampalli, Chandra. / Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams. In: American Journal of Obstetrics and Gynecology. 2012 ; Vol. 206, No. 6.
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    AU - Gao, Haijun

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