Temporal global changes in gene expression during temperature transition in Yersinia pestis

Vladimir L. Motin, Anca M. Georgescu, Joseph P. Fitch, Pauline P. Gu, David O. Nelson, Shalini L. Mabery, Janine B. Garnham, Bahrad A. Sokhansanj, Linda L. Ott, Matthew A. Coleman, Jeffrey M. Elliott, Laura M. Kegelmeyer, Andrew J. Wyrobek, Thomas R. Slezak, Robert R. Brubaker, Emilio Garcia

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


DNA microarrays encompassing the entire genome of Yersinia pestis were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37°C in the presence and absence of Ca2+. Transcriptional profiles revealed that 51, 4, and 13 respective genes and open reading frames (ORFs) on pCD, pPCP, and pMT were thermoinduced and that the majority of these genes carried by pCD were downregulated by Ca2+. In contrast, Ca2+ had little effect on chromosomal genes and ORFs, of which 235 were thermally upregulated and 274 were thermally downregulated. The primary consequence of these regulatory events is profligate catabolism of numerous metabolites available in the mammalian host.

Original languageEnglish (US)
Pages (from-to)6298-6305
Number of pages8
JournalJournal of bacteriology
Issue number18
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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