Single-phoion emission computerized tomography demonstrates temporal-parietal (TP) hypoperfusion in many patients with Alzheimer’s disease (AD). However, the specificity of these changes has not yet been determined. We have found TP hypoperfusion in five groups of patients including I patient with normal aging. 6 with sleep apnea. I with posthypoxic dementia. 5 with multi-infarct dementia and 2 with ‘pseudo’ TP hypoperfusion with frontal seizures. These findings suggest that the TP cortex may be particularly sensitive to hypoxia and/or hypotension and that hypoperfusion to TP Cortex is not specific to AD.
- Hexamethylpropyleneamine oxime
- Single-photon emission computerized tomography
- Sleep apnea
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Cognitive Neuroscience
- Psychiatry and Mental health