Testicular pathological alterations associated with SARS-CoV-2 infection

Judy Ly, Rafael K. Campos, E. Eldridge Hager-Soto, Vidyleison N. Camargos, Shannan L. Rossi

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.

Original languageEnglish (US)
Article number1229622
Pages (from-to)1229622
JournalFrontiers in Reproductive Health
StatePublished - Jun 29 2023


  • COVID-19
  • SARS-CoV-2
  • male reproductive tract
  • testes
  • testicular disease

ASJC Scopus subject areas

  • Epidemiology
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Family Practice


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