TY - JOUR
T1 - Testicular pathological alterations associated with SARS-CoV-2 infection
AU - Ly, Judy
AU - Kroon Campos, Rafael
AU - Hager-Soto, E. Eldridge
AU - Camargos, Vidyleison N.
AU - Rossi, Shannan
N1 - Funding Information:
Institutional funds were used to fund this review. JL, VNC and SR are supported by a grant from the NIH: U19 AI 142762.
Publisher Copyright:
2023 Ly, Campos, Hager-Soto, Camargos and Rossi.
PY - 2023
Y1 - 2023
N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.
AB - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.
KW - COVID-19
KW - male reproductive tract
KW - SARS-CoV-2
KW - testes
KW - testicular disease
UR - http://www.scopus.com/inward/record.url?scp=85164914157&partnerID=8YFLogxK
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U2 - 10.3389/frph.2023.1229622
DO - 10.3389/frph.2023.1229622
M3 - Short survey
C2 - 37457430
AN - SCOPUS:85164914157
SN - 2673-3153
VL - 5
JO - Frontiers in Reproductive Health
JF - Frontiers in Reproductive Health
M1 - 1229622
ER -