Abstract
Sixty-nine patients with stage I testicular seminoma were referred to the Northern Israel Oncology Center between 1968 and 1987. Sixty-four patients were irradiated postoperatively and five patients had surveillance alone. Complete follow-up was available for all patients, with a median follow-up of 86 months (range 9-239 months). The last follow-up was in December 1988. Actuarial survival was 94% to 5, 10, 15, and 20 years. Six patients relapsed following completion of irradiation. All the recurrences occurred outside the radiation field. Three of the relapsed patients could be salvaged with cisplatinum-based chemotherapy and are alive at 4, 7, and 10 years following second-line treatment. Acute or chronic side effects were mild and manageable. Seven patients developed second primary cancers, two within and six outside the radiation field. While surveillance policy alone in stage I testicular seminoma may be successful in terms of patient outcome, it requires prolonged observation, good compliance of patients, and intensive use of resources. Thus, until proved otherwise, infradiaphragmatic radiotherapy should further remain the optimal routine treatment in seminoma patients with stage I disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-179 |
| Number of pages | 5 |
| Journal | Journal of Surgical Oncology |
| Volume | 53 |
| Issue number | 3 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- good prognosis
- radiotherapy
- stage I seminoma
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Testicular seminoma stage I : Treatment results and long-term follow-up (1968-1988). / Stein, M. E.; Kessel, I.; Luberant, N.; Kuten, A.
In: Journal of Surgical Oncology, Vol. 53, No. 3, 1993, p. 175-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Testicular seminoma stage I
T2 - Treatment results and long-term follow-up (1968-1988)
AU - Stein, M. E.
AU - Kessel, I.
AU - Luberant, N.
AU - Kuten, A.
PY - 1993
Y1 - 1993
N2 - Sixty-nine patients with stage I testicular seminoma were referred to the Northern Israel Oncology Center between 1968 and 1987. Sixty-four patients were irradiated postoperatively and five patients had surveillance alone. Complete follow-up was available for all patients, with a median follow-up of 86 months (range 9-239 months). The last follow-up was in December 1988. Actuarial survival was 94% to 5, 10, 15, and 20 years. Six patients relapsed following completion of irradiation. All the recurrences occurred outside the radiation field. Three of the relapsed patients could be salvaged with cisplatinum-based chemotherapy and are alive at 4, 7, and 10 years following second-line treatment. Acute or chronic side effects were mild and manageable. Seven patients developed second primary cancers, two within and six outside the radiation field. While surveillance policy alone in stage I testicular seminoma may be successful in terms of patient outcome, it requires prolonged observation, good compliance of patients, and intensive use of resources. Thus, until proved otherwise, infradiaphragmatic radiotherapy should further remain the optimal routine treatment in seminoma patients with stage I disease.
AB - Sixty-nine patients with stage I testicular seminoma were referred to the Northern Israel Oncology Center between 1968 and 1987. Sixty-four patients were irradiated postoperatively and five patients had surveillance alone. Complete follow-up was available for all patients, with a median follow-up of 86 months (range 9-239 months). The last follow-up was in December 1988. Actuarial survival was 94% to 5, 10, 15, and 20 years. Six patients relapsed following completion of irradiation. All the recurrences occurred outside the radiation field. Three of the relapsed patients could be salvaged with cisplatinum-based chemotherapy and are alive at 4, 7, and 10 years following second-line treatment. Acute or chronic side effects were mild and manageable. Seven patients developed second primary cancers, two within and six outside the radiation field. While surveillance policy alone in stage I testicular seminoma may be successful in terms of patient outcome, it requires prolonged observation, good compliance of patients, and intensive use of resources. Thus, until proved otherwise, infradiaphragmatic radiotherapy should further remain the optimal routine treatment in seminoma patients with stage I disease.
KW - good prognosis
KW - radiotherapy
KW - stage I seminoma
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UR - http://www.scopus.com/inward/citedby.url?scp=0027217201&partnerID=8YFLogxK
M3 - Article
C2 - 8331939
AN - SCOPUS:0027217201
VL - 53
SP - 175
EP - 179
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 3
ER -